Background: Preoperative anxiety is a common condition among patients undergoing surgery and may negatively affect both psychological and physiological well-being. The nurse anesthetist plays a key role in the preoperative encounter and can reduce the patient’s anxiety through strategic interventions. Aim: To describe nurse anesthetists' strategies for alleviating patients' anxiety and worry about anesthesia. Method: An integrative literature review was conducted based on Whittemore and Knafl’s method. Ten scientific articles with both qualitative and quantitative designs were included after systematic database searches and quality appraisal. Results: Two main themes were identified: Recognizing the unique patient and Supportive interventions, along with four subthemes. Strategies such as presence, attentiveness, individualized information, as well as emotional and practical support were found to be central in reducing anxiety. Conclusion: This review presents several strategies that may alleviate preoperative anxiety and worry. These strategies should be adapted to the individual patient. The findings highlight the nurse anesthetist’s opportunity to positively influence patient’s experience through emotional support and tailored communication during the brief preoperativ encounter.