Background: Acute pain is characterized by a sudden onset of discomfort that is often intense but of limited duration. This type of pain can affect the individual both physically and emotionally, placing demands on the nurse’s ability to provide safe, responsive, and personcentered care. Aim: To describe nurses’ experiences of caring for patients with acute pain. Method: A literature review was conducted based on an analysis of twelve scientific articles. Nine of the studies used a qualitative approach, while three were based on a quantitative design. Results: Nurses face several challenges when caring for patients suffering from acute pain. These challenges include inadequate communication, limited knowledge, and a high-pressure work environment. Patients’ ability to actively participate in their pain management is often negatively affected by organizational barriers and nurses’ limited influence in clinical decision-making. Conclusion: To enable nurses to provide safe and individualized care for patients with acute pain, increased competence, clear guidelines, and improved organizational conditions are required. More time for patient encounters and enhanced communication may strengthen the care relationship, increase trust, and contribute to a better care experience.