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  • 1. Chang, E T
    et al.
    Hedelin, M
    Adami, H O
    Gronberg, H
    Bälter, Katarina
    Re: Zinc supplement use and risk of prostate cancer2004In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 96, no 14, p. 1108-1108Article in journal (Refereed)
  • 2. Chang, E. T.
    et al.
    Hedelin, M.
    Adami, H. -O
    Grönberg, H.
    Bälter Augustsson, Katarina
    Karolinska institutet, Sweden.
    Leitzmann, M. F.
    Giovannucci, E.
    Re: Zinc supplement use and risk of prostate cancer (multiple letters) [1]2004In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 96, no 14, p. 1108-1109Article in journal (Refereed)
  • 3. Duggan, D.
    et al.
    Zheng, S. L.
    Knowlton, M.
    Benitez, D.
    Dimitrov, L.
    Wiklund, F.
    Robbins, C.
    Isaacs, S. D.
    Cheng, Y.
    Li, G.
    Sun, J.
    Chang, B. -L
    Marovich, L.
    Wiley, K. E.
    Bälter, Katarina
    Karolinska institutet, Sweden.
    Stattin, P.
    Adami, H. -O
    Gielzak, M.
    Yan, G.
    Sauvageot, J.
    Liu, W.
    Kim, J. W.
    Bleecker, E. R.
    Meyers, D. A.
    Trock, B. J.
    Partin, A. W.
    Walsh, P. C.
    Isaacs, W. B.
    Grönberg, H.
    Xu, J.
    Carpten, J. D.
    Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP2007In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 99, no 24, p. 1836-1844Article in journal (Refereed)
    Abstract [en]

    Background: The consistent finding of a genetic susceptibility to prostate cancer suggests that there are germline sequence variants predisposing individuals to this disease. These variants could be useful in screening and treatment. Methods: We performed an exploratory genome-wide association scan in 498 men with aggressive prostate cancer and 494 control subjects selected from a population-based case-control study in Sweden. We combined the results of this scan with those for aggressive prostate cancer from the publicly available Cancer Genetic Markers of Susceptibility (CGEMS) Study. Single-nucleotide polymorphisms (SNPs) that showed statistically significant associations with the risk of aggressive prostate cancer based on two-sided allele tests were tested for their association with aggressive prostate cancer in two independent study populations composed of individuals of European or African American descent using one-sided tests and the genetic model (dominant or additive) associated with the lowest value in the exploratory study. Results: Among the approximately 60000 SNPs that were common to our study and CGEMS, we identified seven that had a similar (positive or negative) and statistically significant (P<.01) association with the risk of aggressive prostate cancer in both studies. Analysis of the distribution of these SNPs among 1032 prostate cancer patients and 571 control subjects of European descent indicated that one, rs1571801, located in the DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, was associated with aggressive prostate cancer (one-sided P value =. 004). The association was also statistically significant in an African American study population that included 210 prostate cancer patients and 346 control subjects (one-sided P value =. 02). Conclusion: A genetic variant in DAB2IP may be associated with the risk of aggressive prostate cancer and should be evaluated further.

  • 4. Lindmark, F
    et al.
    Zheng, S L
    Wiklund, F
    Bensen, J
    Bälter Augustsson, Katarina
    Karolinska Inst, Stockholm, Sweden.;Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Stanford, USA.
    Chang, B L
    Hedelin, M
    Clark, J
    Stattin, P
    Meyers, D A
    Adami, H O
    Isaacs, W
    Gronberg, H
    Xu, J F
    H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer2004In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 96, no 16, p. 1248-1254Article in journal (Refereed)
    Abstract [en]

    Background: Accumulating epidemiologic and molecular evidence suggest that inflammation is an important component in the etiology of prostate cancer. Macrophage-inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, is thought to play an important role in inflammation by regulating macrophage activity. We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer. Methods: The study population, a population-based case-control study in Sweden, consisted of 1383 prostate cancer case patients and 780 control subjects. From 94 of the control subjects, we constructed gene-specific haplotypes of MIC-1 and identified four haplotype-tagging single-nucleotide polymorphisms (SNPs): Exon1+25 (V9L), Exon1+142 (S48T), IVS1+1809, and Exon2+2423 (H6D). All study subjects were genotyped for the four SNPs, and conditional logistic regression analysis was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results: A statistically significant difference (P = .006) in genotype frequency was observed for the nonsynonymous change H6D) (histidine to aspartic acid at position 6) between prostate cancer patients and control subjects. Carriers of the GC genotype, which results in the H6D change, experienced a lower risk of sporadic prostate cancer (OR = 0.80, 95% CI = 0.66 to 0.97) and of familial prostate cancer (OR = 0.61, 95% CI = 0.42 to 0.89) than the CC genotype carriers. In the study population, the proportion of prostate cancer cases attributable to the CC genotype was 7.2% for sporadic cancer and 19.2% for familial cancer. None of the other SNPs or haplotypes was associated with prostate cancer. Conclusion: This study shows an association between a nonsynonymous change (H6D) in the MIC-1 gene and prostate cancer. This finding supports the hypothesis that genetic variation in the inflammatory process contributes to prostate cancer susceptibility.

  • 5. Sun, J L
    et al.
    Wiklund, F
    Zheng, S L
    Chang, B L
    Bälter, Katarina
    Li, L W
    Johansson, J E
    Li, G
    Adami, H O
    Liu, W N
    Tolin, A
    Turner, A R
    Meyers, D A
    Isaacs, W B
    Xu, J F
    Gronberg, H
    Sequence variants in toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk2005In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 97, no 7, p. 525-532Article in journal (Refereed)
    Abstract [en]

    Background: Chronic inflammation plays an important role in several human cancers and may be involved in the etiology of prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross-talk between innate immunity and adaptive immunity. Our previous finding of an association of TLR4 gene sequence variants and prostate cancer risk provides evidence for a role of TLRs in prostate cancer. In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk. Methods: We selected 32 single-nucleotide polymorphisms (SNPs) covering these three genes and genotyped these SNPs in 96 control subjects from the Cancer Prostate in Sweden (CAPS) population-based prostate cancer case-control study. Five distinct haplotype blocks were inferred at this region, and we identified 17 haplotype-tagging SNPs (htSNPs) that could uniquely describe < 95% of the haplotypes. These 17 htSNPs were then genotyped in the entire CAPS study population (1383 case subjects and 780 control subjects). Odds ratios of prostate cancer for the carriers of a variant allele versus those with the wild-type allele were estimated using unconditional logistic regression. Results: The allele frequencies of 11 of the 17 SNPs were statistically significantly different between case and control subjects (P = .04-.001), with odds ratios for variant allele carriers (homozygous or heterozygous) compared with wild-type allele carriers ranging from 1.20 (95% confidence interval [CI] = 1.00 to 1.43) to 1.38 (95% CI = 1.12 to 1.70). Phylogenetic tree analyses of common haplotypes identified a clade of two evolutionarily related haplotypes that are statistically significantly associated with prostate cancer risk. These two haplotypes contain all the risk alleles of these 11 associated SNPs. Conclusion: The observed multiple associated SNPs at the TLR6-TLR1-TLR10 gene cluster were dependent and suggest the presence of a founder prostate cancer risk variant on this haplotype background. The TLR6-TLR1-TLR10 gene cluster may play a role in prostate cancer risk, although further functional studies are needed to pinpoint the disease-associated variants in this gene cluster.

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