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  • 1.
    Nilsson,, Kenneth
    et al.
    Section of Infectious Diseases, Department of Medical Sciences, Uppsala.
    Påhlson,, Carl
    Mälardalen University, Department of Biology and Chemical Engineering. Section of Infectious Diseases, Department of Medical Sciences, Uppsala.
    Eriksson, Lars
    Uppsala University Hospital, Uppsala, Swedn.
    Nilsson,, Lennart
    Karolinska Institute, Stockholm.
    Lindquist., Olle
    Uppsala University, Uppsala, Sweden.
    Presence of Rickettsia helvetica in granulomatous tissue from three patients with sarcoidosis2002In: The Journal of Infectious Diseases, Vol. 185, no 8, p. 1128-1138Article in journal (Refereed)
    Abstract [en]

    In samples obtained during the autopsies of 2 patients with sarcoidosis, genetic material from Rickettsia helvetica was detected by polymerase chain reaction, and histologic and immunohistochemical examination (using 3 different antibodies) of the polymerase chain reaction-positive tissues showed different degrees of granuloma formation and presence of rickettsia-like organisms predominantly located in the endothelium and macrophages. Electron microscopic examination clearly identified and demonstrated rickettsia-like organisms within the granuloma, with findings suggestive of ongoing infection. Immunogold labeling withProteus OX-19 antiserum showed that the gold markers were localized to the rickettsia-like organisms. Paraffin-embedded biopsy specimens from 30 patients with confirmed sarcoidosis were also reexamined, and 26 specimens were judged to be positive for rickettsia-like organisms by histologic and immunohistochemical examination. In a specimen from 1 patient, rickettsia-like organisms also were demonstrated and identified by transmission electron microscopy. These results support the hypothesis that rickettsiae may contribute to a granulomatous process, as is seen in sarcoidosis.

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