mdh.sePublications
Change search
Refine search result
1 - 26 of 26
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Hellgren, K
    et al.
    Karolinska Institutet, Sweden.
    Hellström, A
    Göteborg University, Göteborg, Sweden.
    Jacobson, L
    Karolinska Institutet, Sweden.
    Flodmark, O
    Karolinska Institutet, Sweden.
    Wadsby, M
    Linköping University, Linköping, Sweden.
    Martin, Lene
    Karolinska Institutet, Sweden.
    Visual and cerebral sequelae of very low birth weight in adolescents.2007In: Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN 1359-2998, E-ISSN 1468-2052, Vol. 92, no 4, p. F259-F264Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To describe the visual functions and relate them to MRI findings and the intellectual level in adolescents born with very low birth weight (VLBW). DESIGN: Population-based case-control study. PATIENTS: 59 15-year-old VLBW adolescents and 55 sex and age-matched controls with normal birth weight. MAIN OUTCOME MEASURES: Objective clinical findings (visual acuity, stereo acuity and cycloplegic refraction) were recorded. Structured history taking was used to identify visual difficulties. The intellectual level was assessed with the Wechsler Intelligence Scale for Children (WISC). All VLBW adolescents underwent MRI of the brain. RESULTS: Significant differences were found between the VLBW adolescents and controls regarding visual acuity (median -0.11 and -0.2, respectively; p=0.004), stereo acuity (median 60'' and 30'', respectively; p<0.001), prevalence of astigmatism (11/58 and 0/55, respectively; p<0.001) and in full-scale IQ (mean IQ 85 and 97, respectively; p<0.001) and performance IQ (mean 87 and 99, respectively; p=0.002). The structured history also revealed a borderline significant difference between the groups (mean problems 0.46 and 0.15 respectively; p=0.051). 30% (17/57) of the VLBW adolescents had abnormal MRI findings and performed worse in all tests, compared with both the VLBW adolescents without MRI pathology and the normal controls. CONCLUSION: This study confirms previous observations that VLBW adolescents are at a disadvantage regarding visual outcome compared with those with normal birth weight. In 47%, visual dysfunction was associated with abnormal MRI findings and in 33% with learning disabilities. The adolescents with abnormal MRI findings had more pronounced visual and cognitive dysfunction. The findings indicate a cerebral causative component for the visual dysfunction seen in the present study.

  • 2.
    Jacobson, Lena
    et al.
    Karolinska University Hospital, Stockholm, Sweden .
    Flodmark, Olof
    Karolinska Institute, Stockholm, Sweden .
    Martin, Lene
    Karolinska Institute, Stockholm, Sweden .
    Visual field defects in prematurely born patients with white matter damage of immaturity: a multiple-case study.2006In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 84, no 3, p. 357-362Article in journal (Refereed)
    Abstract [en]

    PURPOSE: White matter damage of immaturity may affect visual, motor and cognitive functions. This multiple-case study presents standardized perimetry results in six teenagers and young adults born prematurely with visual dysfunction due to white matter damage of immaturity of pre- or perinatal origin. METHODS: Six subjects, aged 13-25 years, born at a gestational age of 28-34 weeks, with white matter damage of immaturity documented by MRI, and optic disc appearances documented by fundus photography, were examined with manual and computerized quantitative perimetry. RESULTS: All subjects had subnormal visual field (VF) function, although the depth and extension of the VF defects differed between subjects. The inferior VF function was more deviant than the superior in all cases. The concordance between the VF defects detected with the different techniques was good, although the static computerized techniques revealed slightly more abnormality. CONCLUSION: White matter damage of immaturity may affect the VF. The lower VF is often more affected than the upper. The abnormalities can be demonstrated by both manual and computerized perimetry.

  • 3.
    Larsson, Eva
    et al.
    Uppsala University Hospital, Uppsala, Sweden.
    Martin, Lene
    Karolinska Institute, Stockholm, Sweden.
    Holmström, Gerd
    Uppsala University Hospital, Uppsala, Sweden .
    Peripheral and central visual fields in 11-year-old children who had been born prematurely and at term2004In: Journal of pediatric ophthalmology and strabismus, ISSN 0191-3913, E-ISSN 1938-2405, Vol. 41, no 1, p. 39-45Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To examine the peripheral and central visual fields in children who had been born prematurely and at term. METHODS: Four groups of 11-year-old children were examined: group 1 included 24 children who had been born at term (control group); group 2 included 20 children who had been born prematurely without ROP; group 3 included 22 children who had been born prematurely with untreated ROP (stages 2 and 3); and group 4 included 21 children who had been born prematurely and underwent cryotreatment for severe ROP. Their peripheral visual fields were examined with Goldmann perimetry. Static high-pass resolution perimetry was used to evaluate their central visual fields within 30 degrees. RESULTS: The peripheral visual fields were constricted in children who had undergone cryotreatment (group 4), as compared with the other groups (1 to 3). We found no difference between the groups of children who had been born prematurely with or without ROP (groups 2 and 3) and the control group. The function of the central visual fields, expressed as neural capacity, was reduced in the children who had been born prematurely compared with the controls, significantly in their left eyes only. The children who underwent cryotreament did not differ from the other children who had been born prematurely in this respect. CONCLUSIONS: The peripheral visual fields were constricted in children who had undergone cryotreatment. It is uncertain whether this was caused by the treatment or by severe ROP. The central visual fields showed a tendency of reduced neural capacity in the children who had been born prematurely, reflecting a reduced density of retinocortical neural channels. However, this was not related to ROP or cryotreatment.

  • 4.
    Malmer, L
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Martin, Lene
    Karolinska Institutet, Stockholm, Sweden.
    Microdot test of foveal function. A comparison with visual acuity at high and low contrast2005In: Ophthalmic & physiological optics, ISSN 0275-5408, E-ISSN 1475-1313, Vol. 25, no 2, p. 81-86Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To define normal values across age from novel computerized tests of foveal vision and to compare the findings with visual acuity (VA) at high and low contrast. SUBJECTS AND METHODS: Sixty-one healthy volunteers, aged 22-87, with subjectively normal vision participated in the study. The right eye from each subject was tested with Snellen letter VA at high contrast, at 10% contrast using the Tri-VA test and with the Rarebit Microdot Fovea Test (RMFT), in addition to biomicroscopy and fundus examination. RESULTS: The median letter VA was 0.77 minimum angle of resolution (MAR; range 0.63-1.54) with a significant decline in letter VA with increasing age (r = 0.7, p < 0.001). The median Tri-VA resolution threshold at 10% contrast was 1.8 MAR (range 0.9-4.1) and a significant age effect (r = 0.7) was observed, most pronounced above 65 years. The median RMFT hit rate was 100% (range 97-100) in the age group below 65 years and 87.5% (range 34-98) in subjects older than 65 years. CONCLUSION: The study shows a decline in foveal function with age with all three methods, reflecting the loss of neural detectors with increasing age. The hit rate to microdot stimuli appears to be a sensitive measure, which can be used for fine-graded evaluation of foveal function.

  • 5.
    Martin, L M
    Karolinska Institute, Stockholm, Sweden.
    Working with glaucoma patients - prospects for "shared care".1999In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 77, no 1, p. 103-106Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To investigate the prospects for "shared care" by evaluating to what extent ophthalmic nurses are involved in ophthalmic care decision tasks in the management of glaucoma patients, how well prepared the nurses feel they are for these tasks and their level of satisfaction in those tasks they actually are performing. METHODS: A questionnaire was sent to the ophthalmic nurses at 13 eye clinics in Sweden. The clinics were selected to represent different parts of Sweden as well as university clinics and smaller rural clinics. RESULTS: A difference was found between clinics regarding the number of tasks independently performed by the ophthalmic nurses and a significant correlation was found between level of participation and satisfaction (p=0.008). The nurses felt prepared for (61/62) and satisfied (58/62) when performing the glaucoma management tasks, and a high and very significant correlation (r=0.96, p= 0.0001) was found between the mean preparedness and satisfaction scores for each of the 14 tasks. CONCLUSIONS: The findings in the study show that the ophthalmic nurses feel prepared for their tasks and regard their involvement in glaucoma care as subjectively satisfactory. These observations support the idea of "shared care" in glaucoma management.

  • 6.
    Martin, L M
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Lindblom, B
    Sahlgrenska University Hospital, Göteborg, Sweden.
    Gedda, U K
    St. Erik Eye Hospital, Stockholm, Sweden.
    Concordance between results of optic disc tomography and high-pass resolution perimetry in glaucoma2000In: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 9, no 1, p. 28-33Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To evaluate concordance between results obtained with the Heidelberg Retina Tomograph (HRT) (Heidelberg Engineering GmbH, Heidelberg, Germany) and those obtained with the high-pass resolution perimeter (HRP) in glaucoma diagnosis. METHODS: A total of 217 patients from the glaucoma services at St. Erik Eye Hospital, Stockholm, Sweden (n = 107) and Sahlgrenska University Hospital, Göteborg, Sweden (n = 110) were included in the study. All patients were examined because of known or suspected glaucoma in at least one eye. The conventional indices presented by the instruments were used, i.e., glaucoma index from the HRT (negative values = abnormal, positive = normal) and combined deviation (upper normal limit 2.1 dB) from the HRP. RESULTS: The concordance regarding the classification of normal or glaucomatous by the two instruments was 71% (153/217 eyes). The HRT indicated glaucoma but HRP findings were normal in 47 patients, and the reverse occurred in 17 patients. There was a significant difference in optic disc area between patients with abnormal HRT findings and normal HRP findings and in patients with normal HRT findings and abnormal HRP findings. The concordance could not be improved by adjusting for disc size. The correlation between combined deviation on HRP and the HRT glaucoma index was r = -0.53. CONCLUSION: A significant correlation was found between the combined index given by HRP and the HRT glaucoma index in 217 patients examined for known or suspected glaucoma. Discordant findings were observed in 64 patients; in 22 this discordance was explained by the influence of disc size. No other reasons for differences in examination results could be detected.

  • 7.
    Martin, Lene
    Mälardalen University, School of Health, Care and Social Welfare. Karolinska Institutet, Stockholm, Sweden.
    Clinical experience with Latanoprost: a retrospective study of 153 patients1999In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 77, no 3, p. 336-339Article in journal (Refereed)
    Abstract [en]

    Purpose: To evaluate the pressure-reducing effect of latanoprost in a clinical setting. Patients and methods: Data from 153 consecutive patients with open angle glaucoma receiving latanoprost were recorded at baseline (=153), 2 weeks (n=151) and 8 to 12 months (n=89) after starting latanoprost treatment, In 82 patients (54%) latanoprost was added to ongoing treatment, Two patients terminated treatment because of side effects before the first follow-up examination, Results: 56% (84/151) of the patients showed an intraocular pressure reduction of 20% or more after 2 weeks, regardless of baseline therapy. The difference between intraocular pressure before (24.4+/-5.8 mm Hg) and after 2 weeks of latanoprost treatment (19.9+/-6.9 mm Hg) in the total group (n=151) was highly significant (p<0.0001). The pressure reduction was significantly correlated,vith the pretreatment intraocular pressure level (r=0.48, p<0.0001). In the 89 patients who could be followed for 8 to 12 months no significant upward drift in mean intraocular pressure was observed, but in fourteen patients intraocular pressure increased with 5 mm Hg or more. Thirteen patients reported side effects, five of these discontinued the treatment. Conclusion: Latanoprost is obviously an efficient pressure reducing drug which can be used in glaucoma patients as an adjunct to any ongoing therapy with the expectation of clinically relevant intraocular pressure reduction in 45-71% of the patients.

  • 8.
    Martin, Lene
    Mälardalen University, School of Health, Care and Social Welfare. Karolinska Institutet, Stockholm, Sweden.
    Computerized method to measure glare and contrast sensitivity in cataract patients1999In: Journal of cataract and refractive surgery, ISSN 0886-3350, E-ISSN 1873-4502, Vol. 25, no 3, p. 411-415Article in journal (Refereed)
    Abstract [en]

    Purpose: To evaluate computerized methods for measuring glare sensitivity and visual acuity at 3 contrast levels in cataract patients. Setting: St. Erik's Eye Hospital, Stockholm, Sweden. Methods: In a prospective study, 25 consecutive cataract patients meeting the inclusion criteria were examined before and 12 weeks after cataract surgery. Measured were glare sensitivity and visual acuity at 3 contrast levels using the Ophthimus Y-VA Contrast Sensitivity lest and Glare Test. Results: Preoperatively, ail patients had impaired values compared with those in a group of age-matched normal volunteers (control group). Postoperatively, median values were similar to those in the age-matched control group in all parameters except glare sensitivity, which was significantly higher in the pseudophakic group (P = .03). Correlation coefficients between preoperative visual acuity and contrast sensitivity at 90%, 25%, and 10% were 0.50 (P = .01), 0.53 (P = .006), and 0.45 (P = .02), respectively, and between preoperative visual acuity and preoperative glare difference, 0.45 (P = .02). A significant correlation was found between age and visual acuity in the control group at all contrast levels: 90% (r = 0.61, P = .0018 ), 25% (r = 0.52, P = .01), and 10% (r = 0.42, P = .04). Median differences between Y-VA examinations (repeatability) were 0 LogMAR except between examinations 1 and 2 at the 25% contrast level, where it was 0.3 LogMAR. Conclusion: The Ophthimus Y-VA Test and Glare Test were useful in the preoperative evaluation of patients with cataract and mild to moderate visual impairment.

  • 9.
    Martin, Lene
    Mälardalen University, School of Health, Care and Social Welfare.
    Dense cataracts lead to amblyopia and visual field impairment in children2008In: Ocular Surgery NewsArticle, review/survey (Other academic)
  • 10.
    Martin, Lene
    Karolinska Institutet, Stockholm, Sweden.
    Intraocular pressure before and after visual field examination2007In: Eye (London. 1987), ISSN 0950-222X, E-ISSN 1476-5454, Vol. 21, no 12, p. 1479-1481Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To evaluate the influence of visual field (VF) examinations using modern techniques with short examination times on the intraocular pressure (IOP). METHODS: Sixty-one consecutive patients, aged 28-90 years, 40 women and 21 men, were examined. Forty patients were treated for glaucoma and 21 were untreated patients with ocular hypertension or suspected glaucoma. Twenty-one subjects were examined using the Humphrey Field Analyzer, using SITA programs, and 40 with high-pass resolution perimetry (HRP). Goldmann applanation tonometry was performed immediately before and after the VF examinations. RESULTS: A difference in IOP of more than 2 mm Hg before and after the VF examination was observed in 14 of the 61 patients (23%). The maximum change in each direction was 4 mm Hg. The mean differences were not significant. All eight subjects with increasing IOP after VF examinations were examined using the HRP technique (P=0.04). CONCLUSION: Modern VF techniques with short examination time do not seem to significantly influence IOP.

  • 11.
    Martin, Lene
    Karolinska Institutet, Sweden.
    Knowledge acquisition and evaluation of an expert system for managing disorders of the outer eye2001In: Computers in Nursing, ISSN 0736-8593, Vol. 19, no 3, p. 114-117Article in journal (Refereed)
    Abstract [en]

    The aim of the current study was to develop and evaluate an expert system for diagnosing outer eye disorders, intended to support family physicians and nurse practitioners in the management of patients with minor eye complaints. The knowledge in the program was gathered from the scientific literature and from 6 experienced ophthalmologists and 6 ophthalmic nurses. Fourteen diagnoses must be considered, and the differential diagnosis is dependent upon 32 signs and symptoms. The program calculates the most likely diagnosis, presents photographs of the typical ocular findings, and provides information regarding management and treatment. The program's output was compared with the diagnosis made by 8 other ophthalmologists at a Swedish university clinic, based on data from 157 patients with disorders of the outer eye, who visited the emergency ward during a one-week period. The concordance between the diagnosis made by the ophthalmologists and the program was 96%. In conclusion, the expert system for disorders of the outer eye provided essentially the same diagnostic information as an examination by an ophthalmologist. Support from the program would make it possible for family physicians and nurse practitioners to manage most of these patients.

  • 12.
    Martin, Lene
    Mälardalen University, School of Health, Care and Social Welfare.
    Medical treatment after argon laser trabeculoplasty in glaucoma1989In: Chibret International Journal of Ophthalmology, ISSN 0748-9501, Vol. 6, no 1, p. 18-21Article in journal (Refereed)
    Abstract [en]

    Medical therapy was reduced or withdrawn in 80 of 160 glaucoma patients with normalized intraocular pressure (IOP) after argon lasertrabeculoplasty (ALT). In the 80 patients with unchanged medical therapy, mean IOP was stable during the six-month follow-up period. Timolol could be withdrawn in a significantly smaller proportion of patients [14 of 28 (50%)] compared to pilocarpine [26 of 32 (81%)]. Acetazolamide could be withdrawn in 14 of 20 patients (70%). The mean IOP increase one month after discontinuance of timolol was 6.6 ± 5.7 mm Hg; after pilocarpine, 4.4 ± 4.7 mm Hg; and after acetazolamide, 4.8 ± 6.3 mm Hg. After six months, IOP remained normal in 13 of the 14 patients (93%) from whom timolol had been withdrawn. Corresponding values were 20 of 26 (77%) for pilocarpine and nine of 14 (64%) for acetazolamide. Thus, medicaltherapy could be discontinued in 54% of patients with normalized IOP after ALT without IOP increase to pathological levels for at least six months.

  • 13.
    Martin, Lene
    Karolinska Institute, Sweden.
    Rarebit and frequency-doubling technology perimetry in children and young adults2005In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 83, no 6, p. 670-677Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To describe the outcome of visual field examinations performed with rarebit (RB) and frequency-doubling technology perimetry (FDT) in children and young adults. METHODS: Twenty-one children (aged 6.5-12 years) and 30 teenagers and young adults (aged 14-20 years), participated in the study. RESULTS: Reliable RB examinations were carried out in 76% of the younger group and 90% of the older group. Corresponding values for FDT were 57% and 90-95%, respectively. The RB results were very similar to those previously obtained in adult subjects, while some subjects showed borderline values in FDT, depending on the criteria used. The RB perimetry was preferred by 88% of the examined subjects. CONCLUSIONS: Rarebit perimetry seems useful for visual field examination in children aged 7 years and over, if age-corrected normative data are established; this test was also preferred by the tested subjects. No adaptation or special instructions were needed and the children found it rather amusing.

  • 14.
    Martin, Lene
    Stockholm University, Sweden.
    'Shared care' and computer assistance in glaucoma management1997In: Studies in Health Technology and Informatics, ISSN 0926-9630, E-ISSN 1879-8365, Vol. 46, p. 288-290Article in journal (Refereed)
    Abstract [en]

    Primary open angle glaucoma afflicts 1-2% of people over 50 years of age. The diagnosis relies on a number of examinations, many of them performed by ophthalmic nurses, and the care of glaucoma patients has become one of their main tasks. A knowledge-based system for decision support in glaucoma management has been developed and validated. The aim of the current study is to evaluate the influence of computerised decision support on a 'shared care' organisation for the management of glaucoma patients.

  • 15.
    Martin, Lene
    Karolinska Institute, Stockholm, Sweden.
    Working with glaucoma patients. Prospects for ‘shared care’1999In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 77, no 1, p. 103-106Article in journal (Refereed)
    Abstract [en]

    Purpose: To investigate the prospects for "shared care" by evaluating to what extent ophthalmic nurses are involved in ophthalmic care decision tasks in the management of glaucoma patients, how well prepared the nurses feel they are for these tasks and their level of satisfaction in those tasks they actually are performing. Methods: A questionnaire was sent to the ophthalmic nurses at 13 eye clinics in Sweden. The clinics were selected to represent different parts of Sweden as well as university clinics and smaller rural clinics. Results: A difference was found between clinics regarding the number of tasks independently performed by the ophthalmic nurses and a significant correlation was found between level of participation and satisfaction (p = 0.008), The nurses felt prepared for (61/62) and satisfied (58/62) when performing the glaucoma management tasks, and a high and very significant correlation (r = 0.96, p = 0.0001) was found between the mean preparedness and satisfaction scores for each of the 14 tasks. Conclusions: The findings in the study show that the ophthalmic nurses feel prepared for their tasks and regard their involvement in glaucoma care as subjectively satisfactory. These observations support the idea of "shared care" in glaucoma management.

  • 16.
    Martin, Lene
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Ley, David
    Karolinska Institutet, Stockholm, Sweden.
    Marsal, Karel
    Karolinska Institutet, Stockholm, Sweden.
    Hellström, Ann
    Sahlgrenska University Hospital/East, Gothenburg, Sweden.
    Visual function in young adults following intrauterine growth retardation2004In: Journal of pediatric ophthalmology and strabismus, ISSN 0191-3913, E-ISSN 1938-2405, Vol. 41, no 4, p. 212-8Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Intrauterine growth retardation (IUGR) resulting in infants born small for gestational age is a known risk factor for neurologic deficits and may predispose to poor cognitive development later in life. We recently found an association between IUGR and a reduced neuroretinal rim area at 18 years of age. We evaluated the possible association between IUGR and visual function. SUBJECTS AND METHODS: We studied 26 subjects who had been born small for gestational age and 20 subjects whose birth weights were appropriate for gestational age (controls) using letter acuity thresholds, color vision testing, full-threshold frequency doubling technology perimetry, and rarebit perimetry at 18 years of age. gestational age had a rarebit hit rate below the normal range as compared with none of the controls (P = .006). These 8 subjects had a significantly smaller rim-disc ratio compared with the subjects who were small for gestational age who had a normal rarebit hit rate (P = .047). The frequency doubling technology indices did not differ significantly between the control group and the group that was small for gestational age, nor did the visual acuity, refraction, and color vision test results. CONCLUSION: These data indicate that IUGR is associated with an increased rate of impaired visual function, which can be detected by using rarebit perimetry but not frequency doubling technology perimetry, visual acuity, or color vision tests.

  • 17.
    Martin, Lene M
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Nilsson, Anna Lundvall
    St. Erik's Eye Hospital, Stockholm, Sweden.
    Rarebit perimetry and optic disk topography in pediatric glaucoma2007In: Journal of pediatric ophthalmology and strabismus, ISSN 0191-3913, E-ISSN 1938-2405, Vol. 44, no 4, p. 223-231Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To determine the relationship between visual field and optic nerve topography findings in a cohort of children with pediatric glaucoma and an age-matched and sex-matched control SUBJECTS AND METHODS: Fifteen children, aged 6 to 15 years, with pediatric glaucoma in at least one eye and 15 age-matched and sex-matched healthy children were examined with best-corrected visual acuity and perimetry. When possible, scanning laser topography of the optic disk (ie, Heidelberg retinal tomography) was performed. RESULTS: Of 27 eyes in 15 children with pediatric glaucoma examined with Goldmann perimetry, 15 eyes (55%) had a normal visual field. Of 24 eyes examined with Rarebit perimetry, 8 eyes (33%) showed normal results and 16 eyes (67%) showed an abnormally low hit rate (ie, the fraction of seen targets vs presented targets). Nine of the 15 eyes showing normal Goldmann visual fields had a subnormal Rarebit hit rate. All children in the control group had normal Rarebit visual fields. Heidelberg retinal tomography could be performed in all healthy children and in 22 eyes of 13 children with pediatric glaucoma. The concordance between the Heidelberg retinal tomography classification (ie, normal or glaucoma) and the Rarebit results was high (Cohen's kappa = 0.79). A statistically significant correlation (r = 0.66, P = .006) between Rarebit hit rate and Heidelberg retinal tomography glaucoma index was found in the glaucoma group. CONCLUSIONS: Rarebit perimetry detected glaucomatous damage in various types of pediatric glaucoma, and can be assumed to be of value in both diagnosis and follow-up. In 13 children with glaucoma, Heidelberg retinal tomography could be performed. The results conformed well to Rarebit findings.

  • 18.
    Martin, Lene
    et al.
    Stockholm University, Sweden.
    Wanger, P
    St. Erik Eye Hospital, Stockholm, Sweden.
    Five-year follow-up of treated patients with glaucoma using resolution perimetry1998In: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 7, no 1, p. 22-6Article in journal (Refereed)
    Abstract [en]

    PURPOSE: The authors describe high-pass resolution perimetry findings during the first five years of antiglaucoma treatment. PATIENTS AND METHODS: Thirty-seven patients were examined six times, once a year for five years, with best corrected visual acuity, applanation tonometry, slitlamp examination, funduscopy, and high-pass resolution perimetry. Twenty-nine of these were treated for glaucoma and eight followed for ocular hypertension without treatment. RESULTS: The resolution thresholds in the treated group improved during the first two years and deteriorated after that back to baseline level. Regarding individual patients, the visual fields were improved in 4, unchanged in 16, and deteriorated in 13 of the 29 treated glaucoma patients at the end of the study period. CONCLUSIONS: Resolution visual fields showed initial improvement and subsequent deterioration in treated patients with early glaucoma. The conventional therapy, aiming at reducing intraocular pressure, appeared to postpone visual field decay for at least five years in about 50% of the patients.

  • 19.
    Martin, Lene
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Wanger, Peter
    St. Erik's Eye Hospital, Sweden.
    New perimetric techniques: a comparison between rarebit and frequency doubling technology perimetry in normal subjects and glaucoma patients2004In: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 13, no 4, p. 268-72Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To compare rarebit microdot perimetry (RB) with frequency doubling technology (FDT) perimetry in normal subjects and a group of patients with ocular hypertension or glaucoma, with age-matched controls. MATERIALS AND METHODS:: Eighty-one subjects (age 17-88 years) were examined. Twenty-seven of these were patients, aged 50 to 88 years, with ocular hypertension or suspected/manifest glaucoma in at least one eye. All subjects were examined with the RB and FDT perimetry, using the standard procedures, recommended by the respective manufacturer. RESULTS: All patients were able to perform the RB perimetry, but three patients could not perceive the strongest FDT stimulus. The concordance in RB and FDT classifications as normal/outside normal limits was 96% (Cohen's kappa = 0.90). A curvilinear (quadratic) relationship (Rsq = 0.75) was found between RB hit rate and FDT MD. All patients, who could perform both examinations, preferred the RB perimetry. CONCLUSION: In the current study, the information from the RB and FDT perimetry was almost completely equivalent. However, RB perimetry was preferred by the patients and seemed to have a larger dynamic range than FDT. The RB hit rate is apparently a straightforward and efficient measure of visual field function.

  • 20.
    Martin, Lene
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Wanger, Peter
    Karolinska Institutet, Stockholm, Sweden.
    Vancea, Lucian
    Sundsvall Hospital, Sundsvall, Sweden.
    Göthlin, Birgitta
    St Eriks Eye Hospital.
    Concordance of high-pass resolution perimetry and frequency-doubling technology perimetry results in glaucoma: no support for selective ganglion cell damage.2003In: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 12, no 1, p. 40-44Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To compare the results of frequency-doubling technology perimetry (FDT), assumed to test the magnocellular visual pathway, and high-pass resolution perimetry (HRP), assumed to test the parvocellular visual pathway, in patients with ocular hypertension or glaucoma. PATIENTS AND METHODS: Forty-eight consecutive patients with glaucoma or ocular hypertension, covering the entire range of optic nerve function from normal to severely damaged, were examined on the same day using FDT and HRP. RESULTS: There was a linear correlation between both global and local indices in FDT and HRP (r = -0.84 P<0.0001 and r = 0.8 P<0.001, respectively). The HRP and FDT classifications agreed in 32 of the 48 (67%) eyes (Cohen kappa = 0.5). There was no significant difference between the ability of the different techniques to detect abnormality. CONCLUSION: The observations in the present study indicate either that both cell populations are similarly affected by glaucomatous damage or that both methods measure activity in the same cell populations.

  • 21. Martin-Boglind, Lene
    Computer-assisted interpretation of resolution visual fields from patients with chiasmal and retrochiasmal lesions1993In: Ophthalmologica, ISSN 0030-3755, E-ISSN 1423-0267, Vol. 207, no 3, p. 148-154Article in journal (Refereed)
    Abstract [en]

    Computer-assisted interpretation of resolution visual fields was performed in 147 normal subjects and 174 consecutive patients with known chiasmal or retrochiasmal lesion. The program identified 99% of normal subjects, and provided support for the correct diagnosis in 64% of patients with chiasmal and 83% of patients with retrochiasmal lesions. In conclusion, computer-assisted interpretation of resolution visual fields can provide considerable support to the final diagnostic decision in patients with lesions of the visual pathways.

  • 22.
    Martin-Boglind, Lene
    Mälardalen University, School of Health, Care and Social Welfare. Sabbatsberg Hospital, Sweden.
    High-pass resolution perimetry in uncomplicated myopia1991In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 69, no 4, p. 516-520Article in journal (Refereed)
    Abstract [en]

    Fifteen subjects (28 eyes) with uncomplicated myopia (3-9 D) were examined using high-pass resolution and Goldmann perimetry. In the central 30 degree field a slight increase was observed in mean resolution threshold significantly correlated to the degree of myopia. In the Goldmann visual fields threshold increase was observed in the area around the blind spot in eight subjects (10 eyes). In the resolution fields only one subject (one eye) showed a corresponding abnormality.

  • 23.
    Martin-Boglind, Lene
    Mälardalen University, School of Health, Care and Social Welfare.
    The effect of treatment on the results of high-pass resolution perimetry in glaucoma1994In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 72, p. 423-428Article in journal (Refereed)
    Abstract [en]

    In order to find out to which extent high-pass resolution perimetry would detect any changes in patients treated for glaucoma, resolution perimetry resultswere evaluated from 56 glaucoma patients and 15 untreated ocular hypertensive patients followed for 2 to 3 years. Fifty-nine of the 71 examined patients showed lower resolution thresholds, i.e. increased sensitivity after 2 years, compared to initial values. The threshold decrease was significantly larger inthe treated glaucoma patients (median 1.22 dB) than in the untreated ocular hypertensive patients (0.48 dB). The threshold decrease in the untreated ocular hypertensive group corresponds to the previously described learning effect. In 35 of the 56 treated glaucoma patients the thresholds improved more than 0.84 dB, the upper confidence limit in the untreated group, which may indicate a beneficial effect of antiglaucoma therapy in these patients.The threshold change was unrelated to initial resolution threshold and cannot be explained by a 'sorting' effect. The observations in the current study using resolution perimetry indicate that improved visual function can be demonstrated in many patients treated for early glaucoma, at least during thefirst 2 years of treatment.

  • 24.
    Martin-Boglind, Lene
    et al.
    Mälardalen University, School of Health, Care and Social Welfare. Sabbatsberg Hospital, Sweden.
    Graves, Adrienne
    Sabbatsberg Hospital, Sweden.
    Wanger, Peter
    Sabbatsberg Hospital, Sweden.
    The effect of topical antiglaucoma drugs on the results of high-pass resolution perimetry1991In: American Journal of Ophthalmology, ISSN 0002-9394, E-ISSN 1879-1891, Vol. 11, no 6, p. 711-714Article in journal (Refereed)
    Abstract [en]

    We conducted a randomly assigned, double-masked, crossover study of the effects of betaxolol, epinephrine, pilocarpine, and timolol on the high-passresolution perimetry results in normal subjects. The influence of topical administration of these intraocular pressure reducing drugs was negligible, which confirmed the reliability of high-pass resolution perimetry results. The method seems appropriate for the diagnosis of glaucoma and the follow-up ofpatients with glaucoma.

  • 25.
    Nilsson, M
    et al.
    Karolinska Institutet, Stockholm, Sweden .
    von Wendt, G
    St. Erik Eye Hospital, Stockholm, Sweden.
    Wanger, P
    Karolinska Institutet, Stockholm, Sweden .
    Martin, Lene
    Karolinska Institutet, Stockholm, Sweden .
    Early detection of macular changes in patients with diabetes using Rarebit Fovea Test and optical coherence tomography2007In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 91, no 12, p. 1596-1598Article in journal (Refereed)
    Abstract [en]

    AIM: To evaluate central retinal thickness and foveal function using optical coherence tomography (OCT) and the Rarebit Fovea Test (RFT) in patients with diabetes without previously known retinopathy or maculopathy. METHOD: Forty-two patients with diabetes mellitus (DM) were selected from the screening records at St Erik Eye Hospital. Inclusion criteria were absence of macular or other retinal changes at previous screening examination and best corrected visual acuity >/=1.0. These patients and 42 healthy controls were examined with the recently developed RFT, and retinal thickness was measured using OCT. Lens thickness and light scatter were evaluated by Scheimpflug photography. RESULTS: Significantly more DM subjects (12/42) had a subnormal RFT result compared with the controls (2/42) (p = 0.007). None of the 12 DM subjects had maculopathy, one had mild non proliferative diabetic retinopathy, and five had minimal non-proliferative diabetic retinopathy. The retinal thickness in the pericentral zone was significantly (p<0.05) thinner in DM patients with subnormal RFT compared with the controls. CONCLUSION: Decreased RT and subnormal RFT results were found in a subgroup of diabetes patients, despite normal screening results. Prospective studies are under way to evaluate the prognostic implications.

  • 26.
    Nilsson, M
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Wanger, P
    Karolinska Institutet, Stockholm, Sweden.
    Martin, Lene
    Karolinska Institutet, Stockholm, Sweden.
    Perception of very small visual stimuli in the fovea: normative data for the Rarebit Foveal Test.2006In: Clinical and experimental optometry, ISSN 0816-4622, E-ISSN 1444-0938, Vol. 89, no 2, p. 81-85Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Conventional visual tests are not sensitive enough to detect low degree neural damage, as 6/6 (1.0) visual acuity can be upheld with less than two-thirds of the normal number of optic nerve axons. The aim of the current study was to evaluate the physiologic properties of a new computerised test, the Rarebit Fovea Test (RFT), using very small stimuli, by quantifying the effect of age and binocular summation in relation to stimulus luminance. METHODS: The RFT relies on the perception of very small (less than 0.5 minutes of arc) bright stimuli. Two different experiments were performed. 1. Thirty-five subjects (age 19 to 63 years) were tested with five different stimulus luminances, 158, 64, 53, 41 and 33 cd/m(2). 2. Nineteen subjects (age 19 to 63 years) were tested using binocular stimulation to define the binocular summation. RESULTS: Significantly reduced median hit rates were observed at luminances of 53 cd/m(2) or below. Age and mean hit rate correlated negatively at all luminance levels below 158 cd/m(2). The mean hit rate from binocular stimulation, compared to the highest value from monocular stimulation in the same subject, was increased by a factor of 1.54 +/- 0.45 (SD). No age effect was found regarding binocular summation. CONCLUSIONS: The results in the current study indicate that RFT can identify some of the well-known features of the visual system, that is, the effects of age and binocular summation, provided that the stimulus luminance is adequately selected.

1 - 26 of 26
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf