In the context of safety-critical product lines, industries have to face an urgent challenge: reduction of time and cost for the creation of a safety case. A safety case is a contextualized structured argument constituted of process and product-based sub-arguments to show that a system is acceptably safe. Its creation is an extremely time-consuming and costly activity. To reduce time and cost, reuse capabilities are being investigated from different perspectives however currently no satisfying approach is available. In this paper, we propose a new methodological framework called Anti-Sisyphus. Anti-Sisyphus is aimed at enabling reuse by combining process lines, product lines and safety case lines. The systematization of what varies and what remains in common with respect to process as well as product elements in turns enables the systematization of what varies and remains in common in terms of process-based as well as product-based arguments within a safety case line. Anti-Sisyphus thus has the potential to enable a 3D reuse.