Cyber-Physical Systems, building on embedded systems and ICT are large complex systems that pose challenges at multiple stages, out of which we mention here design, ownership and utilization. These systems are more and more penetrating our every-day life, impacting on multiple aspects of our activities. In spite of their complexity, or due to that, these systems are offering new opportunities for improving the quality of our lives, simplify our work while helping us to improve the results, and provide support for longer life-spans.