ISO 26262 is a recently introduced automotive functional safety standard. This standard imposes new requirements that must be fulfilled for conformance purposes. Thus, companies used to develop safety-related E/E systems in compliance with either only Automotive SPICE (ASPICE) or a combination of ASPICE and IEC 61508 have to quickly perform a gap analysis in order to introduce adequate changes in their way of working. Implementing such changes in a visionary way with expectations of a long-term payback is an urgent open issue. To contribute to addressing such issue, in this paper, we intro- duce a safety-oriented process line-based methodological frame- work to model commonalities and variabilities (changes) between the standards to enable reuse and flexible process derivation. To show the usefulness of our approach, we apply it to model a proc- ess-phase line for the development of safety-critical control units. Finally, we provide our lessons learned and concluding remarks.