Antonovsky's original observations of mental health among women who had survived Nazi concentration camps became the start for the formulation of sense of coherence (SOC) and suggested that the experience of negative life events can be a risk-factor for, whilst SOC can be a protection-factor against, mental ill-health. In the present study, 1,012 women responded to a questionnaire at two points in time that measured mental ill-health, SOC and the experience of negative life events. The results showed that women who had recently experienced negative life events had higher levels of mental ill-health compared to women who had not recently experienced any negative life events. SOC was also found to have a main effect on mental ill-health but neither moderated nor mediated the relation between negative life events and mental ill-health. Suggestions for future research and practical implications are given. © 2013 Springer Science+Business Media Dordrecht.