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Optic nerve hypoplasia in children and adolescents; prevalence, ocular characteristics and behavioural problems
Karolinska Institutet, Sweden. (S:t Eriks Ögonsjukhus)
Karolinska Universitetssjukhuset, Sweden.
Mälardalen University, School of Health, Care and Social Welfare, Health and Welfare. (Äldres hälsa och välfärd)ORCID iD: 0000-0002-5976-5193
Stockholms Universitet, Sweden.
2014 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 92, no 6, p. 563-570Article in journal (Refereed) Published
Abstract [en]

Purpose: To report prevalence, ocular characteristics and coexisting behavioural problems in children and adolescents with optic nerve hypoplasia (ONH), which is a common cause of visual impairment in children in western countries, often associated with neurological or endocrinological problems and where autism has been reported in severe cases with blindness. Methods: This is a population-based cross-sectional study of patients <20 years of age who had been diagnosed with ONH and lived in the county of Stockholm in December 2009. Ophthalmological assessments including fundus photographs with optic disc analyses were made. A questionnaire was used to screen for behaviour and development. Results: The prevalence of ONH in all living children <18 years of age in Stockholm was 17.3/100 000 with a prevalence of visual impairment (<0.3) of 3.9/100 000. In total, 66 patients, median age 9.3 years (0.6-19.4), 36 with bilateral and 30 with unilateral ONH, were included in the current study; 53 were re-examined clinically, group A, and 13 agreed to retrospective analyses of existing medical records, group B. Analyses of the optic discs were made in fundus photographs from 53 patients comparing a semi-automated (Retinal Size Tool) and a manual method (Zeki). There was a strong curvilinear correlation (rS = -0.91 p < 0.0001 for both eyes). Behavioural problems were more common (p < 0.05) in bilateral ONH. Conclusion: Opticnerve hypoplasia is a common ocular malformation with a prevalence of 17.3/100 000 children and adolescents <18 years of age in Stockholm. Unilateral ONH seems as common as bilateral. 

Place, publisher, year, edition, pages
2014. Vol. 92, no 6, p. 563-570
Keywords [en]
behaviour, disc area, optic nerve hypoplasia, prevalence
National Category
Medical and Health Sciences
Research subject
Care Sciences
Identifiers
URN: urn:nbn:se:mdh:diva-22044DOI: 10.1111/aos.12270ISI: 000340585800033Scopus ID: 2-s2.0-84906318333OAI: oai:DiVA.org:mdh-22044DiVA, id: diva2:658918
Available from: 2013-10-23 Created: 2013-10-23 Last updated: 2017-12-06Bibliographically approved

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