Purpose: The purpose of this paper is to describe the use of computational fluid dynamics (CFD) to simulate indoor radon distribution and ventilation effects. This technique was used to predict and visualize radon content and indoor air quality in a one-family detached house in Stockholm. The effects of intake fans, exhaust fans and doors on radon concentration were investigated. Design/methodology/approach: In this study a mechanically balanced ventilation system and a continuous radon monitor (CRM) were used to measure the indoor ventilation rate and radon levels. In a numerical approach, the FLUENT CFD package was used to simulate radon entry into the building and ventilation effects. Findings: Results of the numerical study indicated that indoor pressure created by ventilation systems and infiltration through doors or windows have significant effects on indoor radon content. The location of vents was found to affect the indoor radon level and distribution. Research limitations/implications: It may be possible to improve any discrepancies found in this article by using a more refined representation of grids and certain boundary conditions, such as pressure and temperature differences between inside and outside and by considering some real situations in residential buildings and external situations. Originality/value: From the viewpoints of indoor air quality (IAQ) and energy savings, ventilation has two opposing functions; on the positive side it enhances IAQ and the establishment of thermal comfort, and on the negative side it increases energy consumption. This paper describes the search for a solution to cope with this contradiction.