Using the classic Quadratic Assignment Problem or Facility Layout problem, this paper attempts to find the optimal formation of three midfielders and three forward football players on ground. Players are treated as “machines”, their positions as locations, and the flow of materials between machines as both “flow of passes” and “flow of markings”. Based on detailed statistics from four matches of AC Milan, and formulated the problem as minimum (quick strategy), maximum (slow strategy), and mixed or balanced strategies, a number of various layouts emerged. The efficiency time gains in the unconditioned layouts are between 3 - 6.8%. When the manager claims that his three forwards shouldn’t shift positions with the midfielders, the unrestricted optimal layouts deteriorate by 7´´ to 20´´, or about 1% of the team’s effective playing time.