mdh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Macular structure and function and the development of retinopathy in diabetes
Karolinska Inst.
St Erik Eye Hosp.
Karolinska Inst.
Karolinska Inst.
Show others and affiliations
2012 (English)In: Clinical and experimental optometry, ISSN 0816-4622, E-ISSN 1444-0938, Vol. 95, no 3, 306-310 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this study was to evaluate the relationship between structural and functional changes identified with the Rarebit fovea test (RFT) in diabetic patients over two years. In addition, we evaluated whether the RFT changes at baseline can predict vascular changes detectable by conventional screening methods four to six years later. Methods: Forty-two patients with diabetes and 42 age-matched healthy subjects underwent an initial examination. Two years later, 25 of the diabetic patients and 20 of the controls were re-examined in the same way. Four to six years later, 40 of the diabetic patients underwent a standard screening examination including fundus photography. After two years, all subjects were examined with the RFT and visual acuity (VA) was assessed. In addition, optical coherence tomography (OCT) and fundus photography were performed on the diabetic patients. At a screening examination of the diabetic patients after four to six years, fundus photographs were reviewed. Results: After two years, a marked difference in RFT results was observed between the 20 normal subjects and the 25 patients with diabetes. Results from other tests (VA and central retinal thickness, as measured with OCT) were unchanged compared with the initial examinations. Fundus photography four to six years later of 40 of the 42 diabetic patients showed an increased incidence of retinopathy unrelated to the RFT findings at baseline. Conclusions: The findings in the current study indicate that the RFT might detect macular dysfunction in diabetic eyes without microvascular changes. This dysfunction increased during a two-year period and presumably reflects neural impairment in diabetes mellitus but did not predict development of retinopathy during the four to six year period.

Place, publisher, year, edition, pages
2012. Vol. 95, no 3, 306-310 p.
Keyword [en]
diabetes, macula, optical coherence tomography, Rarebit fovea test, retinopathy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:mdh:diva-17754DOI: 10.1111/j.1444-0938.2011.00678.xISI: 000304148600008Scopus ID: 2-s2.0-84861212259OAI: oai:DiVA.org:mdh-17754DiVA: diva2:588198
Available from: 2013-01-15 Created: 2013-01-15 Last updated: 2013-12-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Martin, Lene
By organisation
School of Health, Care and Social Welfare
In the same journal
Clinical and experimental optometry
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 114 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf