By appropriating learning from the social and cultural sciences, entrepreneurship and innovation as research fields can be enriched and deepened. Nietzsche can make a contribution to the understanding of entrepreneurship as a matter of transcending the established order, through the creative work of actors. E.g. in order to be able to handle “radical” forms innovation and entrepreneurship, Nietzchean conceptual resources and perspectives can be helpful. He is a philosopher of the unconventional par excellence. An important aspect of transcendence is the overcoming and self-transcendence of the self. The concept of ubermensch by Nietzsche is here intriguing and ambivalent in the reception of his work - seemingly an analogy to the ambivalence of the entrepreneur-hero in the entrepreneurship literature. Closer reading indicate a more complex understanding of men through creative work overcoming themselves, and breaking loose of established customs and norms.