To achieve preferential CO oxidation, a PteCo catalyst-coated channel plate reactor (CCPR)was produced via conventional mechanical milling and catalyst coating. The proposedreactor performed well under a wide range of operating temperatures and providedsatisfactory results at low temperatures (CO concentrations of 1e10 ppm at 413e443 K and1e50 ppm at 413e453 K). In the proposed CCPR, significant deactivation was not observedduring continuous operation for 100 h. In addition, the reactor exhibited excellent toleranceto undesirable conditions, including reaction temperature runaway and feedingstream failure. Characterisation results indicated that the catalytic activity of the proposedCCPR was high due to the formation of Pt3Co intermetallic compounds and nanoscalemetal particles. The capacity per channel of the proposed CCPR was approximately 50e100times greater than those of conventional microchannel reactors; thus, problems associatedwith excessive reactors were significantly reduced. In general, the results indicated thatCCPR has great potential in the small-scale production of hydrogen for fuel cells.