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Microtubule associated proteins 1B and 1S: interactions with NR1 and NR3A
Mälardalen University, School of Sustainable Development of Society and Technology.
2008 (English)Independent thesis Advanced level (degree of Master), 20 points / 30 hpStudent thesis
Abstract [en]

 

In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the N-methyl-D-aspartate receptor subunit NR3A (Eriksson et. al.)1.  In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the microtubule-associated protein 1S carboxyl-terminus and the N-methyl-D-aspartate receptor subunits NR1 and NR3A were examined. The study showed that an interaction occurred between amino acids 2167 to 2365 of the microtubule-associated protein 1B and NR3A.  That region of microtubule associated protein 1B corresponds to a microtubule-binding region in the light chain. It has been shown in earlier studies (Reviewed in Halpain S. et a12, Riederer, BM.  et.al3.) that the light chain is a active part of the protein that have been post translational cleaved. The MAP 1 proteins are present in all tissue but has higher concentrations in the Post Synaptic Density of neurons in the central nervous system.  The N-methyl-D-aspartate receptors are present in glial cells and in the dendritic shafts of the central nervous system neurons (Eriksson et. al.)1 . The diseases were these proteins may play a part is mainly memory destructive diseases such as Alzheimers disease and in muscular dystrophy, but these assumptions are still being speculated.

 

Place, publisher, year, edition, pages
2008. , 19 p.
Keyword
NR1, NR3A, NMDA, Microtubule associated proteins, MAP1S, MAP1B
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:mdh:diva-1197OAI: oai:DiVA.org:mdh-1196DiVA: diva2:37558
Presentation
(English)
Uppsok
fysik/kemi/matematik
Supervisors
Examiners
Available from: 2008-10-13 Created: 2008-10-07 Last updated: 2008-10-13Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • de-DE
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  • en-US
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  • nn-NO
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