mdh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Impact of Enriched environment on Lipid metaboilsm after Experimental Stroke
Mälardalen University, Department of Biology and Chemical Engineering. Mälardalen University, School of Sustainable Development of Society and Technology. (Experimentell hjärnforskning BMC Lund)
2009 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Stroke is the major cause of serious long-term disability with a sufficient acute treatment for only a very limited number of patients. Limited recovery of neurological functions occurs and can be elevated by a permissive post-stroke milieu. Housing animals in an enriched environment modulates regenerative mechanisms in the nonischemic peri-infarct area which might be an attractive target for pharmacological treatments to promote recovery.

Upon ischemia, cellular lipids are released due to massive cell damage and free lipids significantly contribute to the progression of acute and delayed cell death. The aim of this study was to evalute the effect of enriched environment on lipid metabolism. In particular we characterize the activation of the transcription factor liver X receptor (LXR) in glial scar formation and regulation of cholesterol balance of relevance for functional recovery following stroke.                                      Brain tissues from animals subjected to permanent occlusion of middle cerebral artery (pMCAo) were analysed for LXRα and β protein expression. We found an upregulation and an increased transcriptional activity of LXRβ in the peri-infarct area of rats housing in an enriched environment following pMCAO. Our data anticipate that enriched environment may have positive effects on lipid recycling in the ischemic hemisphere following experimental stroke.

Place, publisher, year, edition, pages
2009. , p. 29
Keywords [en]
lipid metabolism, liver X receptor, recovery, enriched environment, astrocytes, apoE, cerebral ischemia, stroke
Identifiers
URN: urn:nbn:se:mdh:diva-6530OAI: oai:DiVA.org:mdh-6530DiVA, id: diva2:226782
Presentation
Wallenberg Neuroscience Center A13, Sölvegatan 17, Lund (English)
Uppsok

Supervisors
Examiners
Available from: 2009-09-24 Created: 2009-07-05 Last updated: 2009-09-24Bibliographically approved

Open Access in DiVA

fulltext(5125 kB)442 downloads
File information
File name FULLTEXT01.pdfFile size 5125 kBChecksum SHA-512
aee0bab98c25e1f19d1643fd3afee1c9ce011582f8e940cfcf4a84372a03d4f280389fec4b752651428baf47f5257998e78a0ae14c13835e13eda7b046ceab7a
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Kuric, Enida
By organisation
Department of Biology and Chemical EngineeringSchool of Sustainable Development of Society and Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 442 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 140 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf