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CONTRIBUTION TO QUANTITATIVE MICROWAVE IMAGING TECHNIQUES FOR BIOMEDICAL APPLICATIONS
Mälardalen University, School of Innovation, Design and Engineering. (Inteligent Sensor Systems)
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This dissertation presents a contribution to quantitative microwave imaging for breast tumor detection. The study made in the frame of a joint supervision Ph.D. thesis between University Paris-SUD 11 (France) and Mälardalen University (Sweden), has been conducted through two experimental microwave imaging setups, the existing 2.45 GHz planar camera (France) and the multi-frequency flexible robotic system, (Sweden), under development. In this context a 2D scalar flexible numerical tool based on a Newton-Kantorovich (NK) scheme, has been developed.

Quantitative microwave imaging is a three dimensional vectorial nonlinear inverse scattering problem, where the complex permittivity of an object is reconstructed from the measured scattered field, produced by the object. The NK scheme is used in order to deal with the nonlinearity and the ill-posed nature of this problem. A TM polarization and a two dimensional medium configuration have been considered in order to avoid its vectorial aspect. The solution is found iteratively by minimizing the square norm of the error with respect to the scattered field data. Consequently, the convergence of such iterative process requires, at least two conditions. First, an efficient calibration of the experimental system has to be associated to the minimization of model errors. Second, the mean square difference of the scattered field introduced by the presence of the tumor has to be large enough, according to the sensitivity of the imaging system.

The existing planar camera associated to a flexible 2D scalar NK code, are considered as an experimental platform for quantitative breast imaging. A preliminary numerical study shows that the multi-view planar system is quite efficient for realistic breast tumor phantoms, according to its characteristics (frequency, planar geometry and water as a coupling medium), as long as realistic noisy data are considered. Furthermore, a multi-incidence planar system, more appropriate in term of antenna-array arrangement, is proposed and its concept is numerically validated.

On the other hand, an experimental work which includes a new fluid-mixture for the realization of a narrow band cylindrical breast phantom, a deep investigation in the calibration process and model error minimization, is presented. This conducts to the first quantitative reconstruction of a realistic breast phantom by using multi-view data from the planar camera. Next, both the qualitative and quantitative reconstruction of 3D inclusions into the cylindrical breast phantom, by using data from all the retina, are shown and discussed. Finally, the extended work towards the flexible robotic system is presented.

Place, publisher, year, edition, pages
Västerås: Mälardalen University , 2009. , 113 p.
Series
Mälardalen University Press Dissertations, ISSN 1651-4238 ; 73
Keyword [en]
Quantitative Microwave Imaging. Inverse Problems, Nonliear Inverse Scattering, Diffraction Tomography, Breast Tumor Detection, Biomedical Imaging, Mammography, Calibration, Modeling, Planar 2.45 GHz Microwave Camera, Robot-based flexible multi-frequency data acquisition
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
URN: urn:nbn:se:mdh:diva-5882ISBN: 978-91-86135-27-0 (print)OAI: oai:DiVA.org:mdh-5882DiVA: diva2:217420
Public defence
2009-06-09, Lambda, Högskoleplan 1, Västerås, 09:30 (English)
Opponent
Supervisors
Projects
Microwaves in biomedicine
Note
A dissertation prepared through an international convention for a joint supervision thesis with Université Paris-SUD 11, FranceAvailable from: 2009-05-14 Created: 2009-05-13 Last updated: 2009-05-25Bibliographically approved
List of papers
1. Comparison Between a 2.45 GHz Planar and Circular Scanners for Biomedical Applications
Open this publication in new window or tab >>Comparison Between a 2.45 GHz Planar and Circular Scanners for Biomedical Applications
2007 (English)In: International Conference on Electromagnetic Near-Field Characterization and  Imaging (ICONIC), St. Louis, MO, USA: International Conference on Electromagnetic Near-Field Characterization and Imaging (ICONIC) , 2007, , 6 p.Conference paper, Published paper (Other academic)
Abstract [en]

Microwave imaging is an efficient technique to non-invasively visualizing dielectricproperties of non-metallic bodies. One potential of the technique is the high contrast in dielectricproperties between biological tissues. In the 80’s, Supélec developed a 2.45 GHz planarmicrowave camera, in the 90’s the group developed algorithms for quantitative microwaveimaging. The purpose of this study is to investigate the capability of these existing materials, oran extended version of them, in terms of quantitative imaging of high-contrast inhomogeneousobject for application of breast cancer detection. A two-dimensional formalization is consideredto be followed up with future three-dimensional investigations.

Place, publisher, year, edition, pages
St. Louis, MO, USA: International Conference on Electromagnetic Near-Field Characterization and Imaging (ICONIC), 2007. 6 p.
Keyword
Quantitative Microwave Imaging, Planar Microwave Camera, Breast Tumor Detection, Newton-Kantorovich
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5876 (URN)
Projects
Microwaves in biomedicine
Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2009-05-13Bibliographically approved
2. Quantitative Imaging Using a 2.45 GHzPlanar Camera
Open this publication in new window or tab >>Quantitative Imaging Using a 2.45 GHzPlanar Camera
2007 (English)In: 5th World Congress on Industrial Process Tomography, Bergen, Norway, Bergen, Norway, 2007, , 8 p.Conference paper, Published paper (Other academic)
Abstract [en]

Microwave imaging is recognized as an efficient diagnostic modality for no invasively visualizingdielectric contrasts in non metallic bodies. The usefulness of this modality results from the existingcorrelation between dielectric properties and quantities of practical relevance for industrial orbiomedical applications. At the beginning of the 80’s, Supélec developed a 2.45 GHz planarmicrowave camera, in the 90’s the group developed algorithms for quantitative microwave imaging.The purpose of this study is to investigate the capability of these existing materials, or an extendedversion of it, in terms of quantitative imaging of high contrast inhomogeneous object for application ofbreast cancer detection.

Place, publisher, year, edition, pages
Bergen, Norway: , 2007. 8 p.
Series
World Congress on Industrial Process Tomography, 5
Keyword
Quantitative Microwave Imaging, Planar Microwave Camera, Breast Tumor Detection, Newton-Kantorovich algorithm
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5877 (URN)
Projects
Microwaves in biomedicine
Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2009-05-13Bibliographically approved
3. Quantitative Microwave Breast Phantom Imaging Using a Planar 2.45 GHz System
Open this publication in new window or tab >>Quantitative Microwave Breast Phantom Imaging Using a Planar 2.45 GHz System
Show others...
2008 (English)In: (Supélec), XXIX General Assembly of URSI, International Union of Radio Science, Chicago, MO, USA, August, 2008, Chicago, Illinois, USA: XXIX General Assembly of the International Union of Radio Science, URSI , 2008, , 4 p.Conference paper, Published paper (Other academic)
Abstract [en]

Breast cancer is a global health problem, needing cheep and effective alternative diagnosis methods in order to minimize the mortality. This experimental study is performed in the context of an ongoing collaborative project towards a future planar three-dimensional microwave breast mammography system. Herein the first quantitative image of an inhomogeneous breast tumor phantom, composed by different Triton X-100/water/salt mixtures, is obtained by using the existing planar 2.45 GHz microwave camera.

Place, publisher, year, edition, pages
Chicago, Illinois, USA: XXIX General Assembly of the International Union of Radio Science, URSI, 2008. 4 p.
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5884 (URN)
Projects
Microwaves in biomedicine
Available from: 2009-05-14 Created: 2009-05-13 Last updated: 2009-05-14Bibliographically approved
4. Robot Controlled Data Acquisition System for Microwave Imaging
Open this publication in new window or tab >>Robot Controlled Data Acquisition System for Microwave Imaging
2009 (English)In: 3rd European Conference on Antennas and Propagation, 2009, , 5 p.3240-3244 p.Conference paper, Published paper (Refereed)
Abstract [en]

In this paper an experimental prototype of a robot controlled data acquisition system for microwave imaging is presented, where the transmitting and receiving antennas are immersed in a water-tank. The scattered field from the object under test is acquired by using the robot and scanning a single receiving antenna in cylindrical or half spherical coordinates, while the transmitting antenna is fixed at one position with possibilities to be manually moved to different positions. Careful design and construction of the system has given accurate measurements of incident and total field with a SNR of 45dB. A validation of the robot system is performed by comparing measured and computed data for a sunflower oil object.In this paper an experimental prototype of a robot controlled data acquisition system for microwave imaging is presented, where the transmitting and receiving antennas are immersed in a water-tank. The scattered field from the object under test is acquired by using the robot and scanning a single receiving antenna in cylindrical or half spherical coordinates, while the transmitting antenna is fixed at one position with possibilities to be manually moved to different positions. Careful design and construction of the system has given accurate measurements of incident and total field with a SNR of 45dB. A validation of the robot system is performed by comparing measured and computed data for a sunflower oil object.

Publisher
5 p.
Keyword
Microwave Imaging, data acquisition, experimental data, monopole antenna, system validation
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5895 (URN)000276522101309 ()978-1-4244-4753-4 (ISBN)
Conference
3rd European Conference on Antennas and Propagation Location: Berlin, GERMANY Date: MAR 23-27, 2009
Projects
Microwaves in biomedicine
Available from: 2009-05-14 Created: 2009-05-14 Last updated: 2014-12-08Bibliographically approved
5. Quantitative Microwave Imaging for Breast Cancer Detection Using a Planar 2.45 GHz System
Open this publication in new window or tab >>Quantitative Microwave Imaging for Breast Cancer Detection Using a Planar 2.45 GHz System
2012 (English)In: IEEE Transactions on Instrumentation and Measurement, ISSN 0018-9456, Vol. 59, no 10, 2691-2699 p.Article in journal (Other academic) Published
Abstract [en]

Microwave imaging is recognized as a potentialcandidate for biomedical applications, such as breast tumordetection. In this context a planar microwave camera isinvestigated for quantitative imaging of inhomogeneous objects.Promising simulation results indicates that the planar geometryis suitable for quantitative imaging, as long as the signal to noiseratio is higher than 40 dB. Different calibration techniques arediscussed with several proposed model improvements and thefirst reconstructed quantitative image of an inhomogeneous 2Dobject is obtained by using experimental data from the camera.

Keyword
Microwave Imaging, Nonlinear Inverse Scattering, Breast Cancer Detection, Mammography
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5879 (URN)10.1109/TIM.2010.2045540 (DOI)000283263900022 ()2-s2.0-77956755677 (Scopus ID)
Projects
Microwaves in biomedicine
Note

Submitted to IEEE Transaction on Instrumentation and Measurement: IM-09-2086 "©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE."

Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2013-07-30Bibliographically approved
6. Breast Tumor Detection Ability Using aPlanar 2.45 GHz System
Open this publication in new window or tab >>Breast Tumor Detection Ability Using aPlanar 2.45 GHz System
(English)Manuscript (Other academic)
Abstract [en]

This paper deals with the breast tumor detectionability of a planar microwave imaging system. Indeed, microwaveimaging seems to have a significant potential in such a biomedicalapplication. By means of a numerical model based upon electricfield volume integral equations, we investigate the influence ofseveral parameters, such as the respective sizes of the breastand the tumor, the operating frequency and the electromagneticproperties of the different media, on the detection ability. Thelatter is estimated by comparing the scattered fields observed inthe presence and in the absence of tumor and by accounting forthe signal to noise ratio available with the experimental setupdeveloped at the laboratory.

Keyword
Breast Cancer Detection, Microwave Imaging
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:mdh:diva-5880 (URN)
Projects
Microwaves in biomedicine
Note
Submitted to IEEE Transaction on Medical Imaging "©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE." Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2010-01-14Bibliographically approved

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