This chapter illustrates the contribution that practice theories have offered to the ongoing conversation on critical posthumanism and how this conversation has shaped in its turn a stream of practice theorization. It offers two points of entry: a conception of practice as agencement and the sociomateriality of situated practices and it argues that the main contribution that a posthumanist practice theory offers to posthumanism is a methodological reflection for re-thinking qualitative empirical research once the human subject (and the humanist predicament associated to the Man of reason) has been decentered. It constitutes an experimentation with posthumanist qualitative inquiry, in which research practices do not “represent” reality, rather they explore various knowledge-producing practices and how different ways of producing reality have different social, economic, and political effects.