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The scientific community has widely recognized thermosensitive hydrogelsas highly biocompatible material withimmense potential in drug deliverysystems. When the temperature of these hydrogels approaches that ofhuman body, a phase change occurs, enhancing their usefulness in a rangeof medical scenarios. This review article highlighted the background ofthermosensitive hydrogels, their properties, and their applications intransdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy,and cell‐loaded drug delivery systems. The literature suggests numerousadvantages of these hydrogels over conventional drug delivery systems andfind applications in various fields, such as therapeutic systems, fillingprocesses, and sustained drug delivery systems. One of their key benefits isthe ability to eliminate invasive procedures like surgery, providing anoninvasive alternative for drug administration. Moreover,theystreamlinethe formulation process for both hydrophilic and hydrophobic drugdelivery systems, simplifying the development of effective treatments.The thermosensitive hydrogels have been found to be green materials withnegligible side effects and desirable drug delivery properties. Thethermosensitive hydrogel's sustained‐release characteristics, immunogenic-ity, and biodegradability have also gained increased interest. Some of thedisadvantages of thermosensitive hydrogels include delayed temperatureresponse, weak mechanical characteristics, and poor biocompatibility,which limits their potential use in drug delivery applications.