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Exploring preferences of at-risk individuals for preventive treatments for rheumatoid arthritis
Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID iD: 0000-0003-2596-9101
Centre for Research Ethics & Bioethics, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0002-5865-5590
Freelance Healthcare Data Scientist, Eckental, Germany;Department of Internal Medicine and Institute for Clinical Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID iD: 0000-0003-0228-7183
Patient Research Partner, Swedish Rheumatism Association, Stockholm, Sweden.
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2022 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, p. 1-11Article in journal (Refereed) Published
Abstract [en]

Objective Some immunomodulatory drugs have been shown to delay the onset of, or lower the risk of developing, rheumatoid arthritis (RA), if given to individuals at risk. Several trials are ongoing in this area; however, little evidence is currently available about the views of those at risk of RA regarding preventive treatment. Method Three focus groups and three interviews explored factors that are relevant to first degree relatives (FDRs) of RA patients and members of the general public when considering taking preventive treatment for RA. The semi-structured qualitative interview prompts explored participant responses to hypothetical attributes of preventive RA medicines. Transcripts of focus group/interview proceedings were inductively coded and analysed using a framework approach. Results Twenty-one individuals (five FDRs, 16 members of the general public) took part in the study. Ten broad themes were identified describing factors that participants felt would influence their decisions about whether to take preventive treatment if they were at increased risk of RA. These related either directly to features of the specific treatment or to other factors, including personal characteristics, attitude towards taking medication, and an individual's actual risk of developing RA. Conclusion This research highlights the importance of non-treatment factors in the decision-making process around preventive treatments, and will inform recruitment to clinical trials as well as information to support shared decision making by those considering preventive treatment. Studies of treatment preferences in individuals with a confirmed high risk of RA would further inform clinical trial design.

Place, publisher, year, edition, pages
2022. p. 1-11
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:mdh:diva-62341DOI: 10.1080/03009742.2022.2116805ISI: 000863392400001PubMedID: 36178461Scopus ID: 2-s2.0-85141039395OAI: oai:DiVA.org:mdh-62341DiVA, id: diva2:1753450
Available from: 2023-04-27 Created: 2023-04-27 Last updated: 2023-10-23Bibliographically approved

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Schölin Bywall, Karin

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Simons, GSchölin Bywall, KarinEnglbrecht, MDiSantostefano, RLRadawski, CVeldwijk, JRaza, KFalahee, M
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Rheumatology and Autoimmunity

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