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Changes in Appetite During the Heart Failure Trajectory and Association With Fatigue, Depressive Symptoms, and Quality of Life
Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.ORCID iD: 0000-0002-1482-767X
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands..
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands..
Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden..
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2021 (English)In: Journal of Cardiovascular Nursing, Vol. 36, no 6, p. 539-545Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Decreased appetite can contribute to malnutrition in patients with heart failure (HF). Little is known about the trajectory of appetite over time in patients with HF and the factors associated with decreased appetite after discharge from the hospital. OBJECTIVE: The aims of this study were to investigate changes in appetite over time and explore how fatigue, depressive symptoms, and quality of life are associated with decreased appetite. METHODS: Data from the multicenter randomized Coordinating study evaluating Outcomes of Advising and Counseling in Heart Failure were used. Logistic regression and mixed-effects logistic regression were used to investigate changes in appetite over time and to explore the relationship between appetite and fatigue, depressive symptoms, and quality of life. RESULTS: A total of 734 patients with HF (mean age, 69 years) were included. Decreased appetite was present at all follow-up measurements; however, decreased appetite was significantly lower at the 1-month (odds ratio [OR], 0.43; confidence interval [CI], 0.29-0.63), 6-month (OR, 0.31; CI, 0.20-0.47), 12-month (OR, 0.22; CI, 0.14-0.34), and 18-month (OR, 0.24; CI, 0.15-0.37) follow-ups compared with baseline. Decreased appetite was associated with fatigue (OR, 3.09; CI, 1.98-4.84), depressive symptoms (OR, 1.76; CI, 1.35-2.29), and low quality of life (OR, 1.01; CI, 1.01-1.02) across all measurement points adjusted for covariates. CONCLUSIONS: Appetite improved after discharge; however, at all time points, at least 22% of patients reported decreased appetite. Fatigue, depressive symptoms, and low quality of life are factors associated with decreased appetite. Decreased appetite is a long-standing problem in that it does not disappear spontaneously after an acute HF deterioration.

Place, publisher, year, edition, pages
2021. Vol. 36, no 6, p. 539-545
Keywords [en]
appetite, depressive symptoms, fatigue, heart failure, quality of life
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:mdh:diva-61878DOI: 10.1097/JCN.0000000000000756ISI: 000756652700005PubMedID: 33136703Scopus ID: 2-s2.0-85118597944OAI: oai:DiVA.org:mdh-61878DiVA, id: diva2:1736280
Note

Funding: Netherlands Heart FoundationNetherlands Heart Foundation [2000Z003]; Biosite France SAS; Jouy-en-Josas, France (brain natriuretic peptide); Roche Diagnostics Nederland BV, Venlo, the Netherlands; Novartis Pharma BV, Arnhem, the NetherlandsNetherlands Government

Available from: 2023-02-13 Created: 2023-02-13 Last updated: 2023-04-12Bibliographically approved

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