Systemic innovation as a concept and theory is still undeveloped fo runderstanding and managing innovation. By a focus on processes where actors innovate systemically, where systems are seen as something constructed byinnovators rather than given in reality, systemic innovation adds to leading approaches to managing innovation, like open innovation, triple helix, as wellas innovation system and ecosystem, with potentials to be developed into a new paradigm in innovation studies and innovation management. Through conceptual development, literature review and empirical study at three industrial innovation centers focused on industry transformation, a model for systemic innovation is developed. The model aims to contribute to theory of systemic innovation as well as be potential guide for practitioners in innovating systemically