This study investigates how the different political opportunity structures (POS) are related to NGO mobilization in two Chinese cities, Guangzhou and Hangzhou. Based on 48 interviews from 2016–2019, the study finds that variance in NGO mobilization is related to differences such as rules for NGO registration, more or less open-minded local leaders, and a relatively more independent media. NGO governance in Hangzhou is characterized as coopted participation. A few NGOs are allowed some influence in policy making, but in order to be allowed to mobilize, NGOs must accept a certain degree of cooptation. NGO governance in Guangzhou is characterized as constrained autonomy as the government plays a less active role in mobilizing NGOs, and more initiative for policy influence comes from the NGOs themselves.