The purpose of this study was to determine the management of anthelmintic administration and the possibility of drug resistance in laying hens in Blitar and Kediri districts in Indonesia. This study consisted of two stages: first surveying 48 farmers in Blitar and 81 farmers in Kediri to find out how anthelmintic administration management included the frequency of anthelmintic administration for laying hens, types of anthelmintic, the habit of farmers using sustainably the same (> 3 yr) type of anthelmintic, determination of dosage, and use of herbal medicines in controlling worm disease. In the second stage, examine worm eggs at laying hens farms treated with worm medicine at intervals of 2 wk to 4 wk. The results showed that the majority of laying hens provide anthelmintic every 2 mo to 3 mo. In Blitar, the number of farmers who used the same worm medicine in more than 3 yr was 83.33 %. While in Kediri the number reached 97.53 %. The number of farmers who determined anthelmintic doses based on chicken body weight was 95.84 % (Blitar) and 90.12 % (Kediri). The administration of the same type of anthelmintic for more than three consecutive years and the calculation of anthelmintic doses based on the average body weight is thought to have an influence on the occurrence of drug resistance. It is seen that even though chickens were treated with anthelmintic for only 2 wk to 4 wk, worm eggs were found in fecal examination. © Pakistan Academy of Sciences.