Liquefaction and digitalization are important socio-technical changes that call for actions in education. As stated by Bauman, as a consequence of liquification (and digitalization), uncertainty is increasing. Within this socio-technical context, in this paper, we focus on the necessity of reframing the role of the safety engineer and on the transformative educational change necessary to enable the re-framed safety engineers to cope with uncertainty. We posit that the 21st Century safety engineer is expected to develop antifragility. To contribute to that development and thus educate/ex- dūcĕre antifragility from future (safety) engineers, we focus on one course (code DVA437, aimed at teaching safety-critical systems engineering) and we plan its 21st Century-oriented transformative educational change. We also report about the first iteration of the design of the personal opinion survey that we intend to use for validating our plan, before proceeding with its implementation.