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Effect of combined treatment with R-(+)-methanandamide and chemotherapeutic drugs in mantle cell lymphoma and chronic lymphocytic leukemia: MCL
Mälardalen University. Mälardalen University, School of Health, Care and Social Welfare. Mälardalen University, School of Sustainable Development of Society and Technology. (Dep. of Laboratory Medicine, Division of Pathology, KI.)
(English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Mantle cell lymphoma (MCL) is a non-Hodgkin B-cell lymphoma with very bad prognosis. The genetic hallmark of MCL, is the translocation t(11;14)(q13;q32) which leads to overexpression of cyclin D1, a D-type cyclin that is not usually expressed at high levels in normal B lymphocytes.

 

Previous studies indicate that cannabinoid receptors are expressed in lymphoma and have shown that lymphoma cell death is induced as a result of exposure to cannabinoids (ligands).

 

The aim of this diploma work was to combined cytostatics with the cannabinoid receptor ligand R (+)-Methanandmide (R-MA). Our data suggest that combination treatment with cytostatics and R-MA induces synergistic effects in most cases.

National Category
Medical and Health Sciences Pharmacology and Toxicology Dentistry Chemical Engineering Medical Bioscience
Identifiers
URN: urn:nbn:se:mdh:diva-4876OAI: oai:DiVA.org:mdh-4876DiVA: diva2:158870
Presentation
, Mälardalens Högskola, Eskilstuna (English)
Uppsok
fysik/kemi/matematik
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Available from: 2009-04-16 Created: 2009-02-04 Last updated: 2009-04-16Bibliographically approved

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Thirugnanam, Vasanthakumar
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