Background: Palliative care is given to patients when curative treatment is no longer possible to alleviate suffering and improve quality of life. Previous research shows that patients in palliative care experience depression, fear of suffering and fear of the unknown after death. In palliative care, it is the nurse’s responsibility to create a holistic view based on their unique needs and requirements. By being present to provide support to patients’ and relatives’ to achieve an increased quality of life until the end. Aim: To describe nurses experience of palliative care at the end of life. Method: Qualitative literature study with a describing synthesis. Results: Nurses' experience a lack of knowledge in dealing with patients’ and relatives’ emotional and psychological needs in end-of-life care. Nurses share a need for emotional support from colleagues to experience an increased sense of self-confidence in their professional roles. Conclusion: Nurses' experience a lack of knowledge, which prevents them from offering optimal care to their patients based on their needs and requirements. Therefore, there is a need for more education to experience increased security in their professional role and upon meetings with patients and relatives in palliative care.