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Impact of subthreshold transcutaneous auricular vagus nerve stimulation on the heart rate variability and atrial arrhythmias
Jožef Stefan Institute, Department of Communication Systems, Ljubljana, Slovenia.
Mälardalen University, School of Innovation, Design and Engineering, Embedded Systems.ORCID iD: 0000-0003-1940-1747
University Medical Centre, Department of Cardiology, Ljubljana, Slovenia.
2020 (English)In: 2020 43rd International Convention on Information, Communication and Electronic Technology, MIPRO 2020 - Proceedings, Institute of Electrical and Electronics Engineers Inc. , 2020, p. 349-354Conference paper, Published paper (Refereed)
Abstract [en]

Dysfunction of cardiac intrinsic autonomic nervous system could be one of possible triggers for atrial fibrillation. Different studies show that it is possible to modulate the cardiac intrinsic autonomic activity with electrical stimulation through the skin in the ear, innervated by auricular branch of the vagus nerve (tVNS). The aim of our study was to determine, weather tVNS reduces the burden of atrial arrhythmias in patients with paroxysmal atrial fibrillation. A randomised double-blind study, with one-hour daily subthreshold tVNS, over three-day blocks of sham or true stimulation, was performed. A continuous single-channel ambulatory ECG was recorded. Significant technical assistance to computer-based ECG interpretation was necessary for highest possible interpretation quality. The obtained results were compared between periods with true and sham stimulation to discover eventual differences. We have successfully validated the designed methodology. The subthreshold tVNS has a detectable impact on heart rate variability. However, there was no significant impact of tVNS on the burden of atrial arrhythmias. A 3-day tVNS is probably too short for such evaluation.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers Inc. , 2020. p. 349-354
Keywords [en]
AF burden, Atrial arrhythmias, Auricular vagal nerve, ECG body sensor; auricular vagal nerve; heart rate variability, Electrical stimulation, Electrical stimulation, tVNS, ECG body sensor, Heart rate variability, HRV, HRV; AF burden; atrial arrhythmias, TVNS, Computer aided analysis, Diseases, Electrocardiography, Atrial fibrillation, Autonomic activity, Autonomic nervous system, ECG interpretation, Electrical stimulations, Heart rate variability, Paroxysmal atrial fibrillations, Technical assistance, Heart
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:mdh:diva-52863DOI: 10.23919/MIPRO48935.2020.9245390ISI: 000790326400066Scopus ID: 2-s2.0-85097234946ISBN: 9789532330991 (print)OAI: oai:DiVA.org:mdh-52863DiVA, id: diva2:1511103
Conference
43rd International Convention on Information, Communication and Electronic Technology, MIPRO 2020, Opatija, Croatia, 28 September through 2 October 2020
Available from: 2020-12-17 Created: 2020-12-17 Last updated: 2022-11-23Bibliographically approved

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Lindén, Maria

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