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Genotypes Do Not Confer Risk For Delinquency ut Rather Alter Susceptibility to Positive and Negative Environmental Factors: Gene-Environment Interactions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR
Uppsala Univ, Cty Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden..ORCID iD: 0000-0002-8853-2508
Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden..ORCID iD: 0000-0002-2174-2068
Karolinska Inst, Stockholm, Sweden.;Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada..
Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden..
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2015 (English)In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 18, no 5Article in journal (Refereed) Published
Abstract [en]

Background: Previous evidence of gene-by-environment interactions associated with emotional and behavioral disorders is contradictory. Differences in findings may result from variation in valence and dose of the environmental factor, and/or failure to take account of gene-by-gene interactions. The present study investigated interactions between the brain-derived neurotrophic factor gene (BDNF Val66Met), the serotonin transporter gene-linked polymorphic region (5-HTTLPR), the monoamine oxidase A (MAOA-uVNTR) polymorphisms, family conflict, sexual abuse, the quality of the child-parent relationship, and teenage delinquency. Methods: In 2006, as part of the Survey of Adolescent Life in Vastmanland, Sweden, 1 337 high-school students, aged 1718 years, anonymously completed questionnaires and provided saliva samples for DNA analyses. Results: Teenage delinquency was associated with two-, three-, and four-way interactions of each of the genotypes and the three environmental factors. Significant four-way interactions were found for BDNF Val66Met x 5-HTTLPRxMAOA-uVNTR x family conflicts and for BDNF Val66Met x 5-HTTLPRxMAOA-uVNTR x sexual abuse. Further, the two genotype combinations that differed the most in expression levels (BDNF Val66Met Val, 5-HTTLPR LL, MAOA-uVNTR LL [girls] and L [boys] vs BDNF Val66Met Val/Met, 5-HTTLPR S/LS, MAOA-uVNTR S/SS/LS) in interaction with family conflict and sexual abuse were associated with the highest delinquency scores. The genetic variants previously shown to confer vulnerability for delinquency (BDNF Val66Met Val/Met x 5-HTTLPR S x MAOA-uVNTR S) were associated with the lowest delinquency scores in interaction with a positive child-parent relationship. Conclusions: Functional variants of the MAOA-uVNTR, 5-HTTLPR, and BDNF Val66Met, either alone or in interaction with each other, may be best conceptualized as modifying sensitivity to environmental factors that confer either risk or protection for teenage delinquency.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2015. Vol. 18, no 5
Keywords [en]
brain-derived neurotrophic factor, gene-environment interaction, juvenile delinquency, monoamine oxidase, serotonin plasma membrane transport proteins
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:mdh:diva-52013DOI: 10.1093/ijnp/pyu107ISI: 000352538100016PubMedID: 25522433Scopus ID: 2-s2.0-84931274371OAI: oai:DiVA.org:mdh-52013DiVA, id: diva2:1484408
Available from: 2020-10-28 Created: 2020-10-28 Last updated: 2021-01-20Bibliographically approved

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Nilsson, Kent W.

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