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Serotonin transporter genotype by environment: Studies on alcohol use and misuse in non-human and human primates
Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden..
Vasteras Hosp, Ctr Clin Res, S-72189 Vasteras, Sweden..ORCID iD: 0000-0002-8853-2508
Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden..
Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.;Kings Coll London, Inst Psychiat, London WC2R 2LS, England..ORCID iD: 0000-0002-3436-7121
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2013 (English)In: Translational Neuroscience, ISSN 2081-3856, E-ISSN 2081-6936, Vol. 4, no 2, p. 241-250Article, review/survey (Refereed) Published
Abstract [en]

Much evidence indicates that gene-by-environment interactions (GxE) play a role in alcohol misuse. It has been proposed that interactions between serotonin and stress confer vulnerability for alcohol misuse. The present review examined studies of the interaction between the serotonin transporter linked polymorphic region (5-HTTLPR) genotype and stressful life events and alcohol-related phenotypes, in rhesus monkeys and humans. Ten studies were found that had investigated the interaction of 5-HTTLPR and various measures of stress and alcohol use or misuse, two studies of rhesus monkeys, and eight of humans. The results are contradictory. Important differences were reported in study samples, experimental designs, measures used to assess environmental variables, definitions and measurements of alcohol-related phenotypes, and in the statistical analyses. These differences may explain the contradictory results. Guidelines for future studies are suggested. Results are discussed in light of findings from molecular, non-human animal, and clinical studies. The review highlights the need for future studies examining associations of interactions between the serotonin transporter gene and environmental factors and alcohol misuse, especially in samples followed over time.

Place, publisher, year, edition, pages
DE GRUYTER POLAND SP ZOO , 2013. Vol. 4, no 2, p. 241-250
Keywords [en]
Alcohol, Alcohol use disorder, Association, Environment, Gene, Genotype, Interaction, Primates, Serotonin transporter, 5-HTTLPR
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Clinical Medicine
Identifiers
URN: urn:nbn:se:mdh:diva-52026DOI: 10.2478/s13380-013-0121-6ISI: 000320338200009Scopus ID: 2-s2.0-84885028018OAI: oai:DiVA.org:mdh-52026DiVA, id: diva2:1484390
Available from: 2020-10-28 Created: 2020-10-28 Last updated: 2021-01-20Bibliographically approved

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Nilsson, Kent W.

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