This paper analyses four episodes of commercialization of science taken from the innovation practices of two major Swedish universities, Karolinska Institutet and Uppsala University. The four mini-cases (PET center, Ångström Materials Academy, Actar AB, and Karolinska Development) were selected to provide variation in the commercialization mechanisms and goals. Our purpose is to relate the patterns of control and governance in each episode with its goal and commercialization mechanism. In doing this we also discuss the impact that the number and typology of actors involved, as well as their relationships, have on how control is exerted in each commercialization episode.