In manufacturing and automation systems, there is an increasing need for switching to new paradigms instead of merely upgrading the technological systems. More specifically, manufacturing and automation systems should move towards holonic and intelligent paradigms, featuring a set of advantages with respect to legacy systems based on traditional approaches. In this position paper, we address those advantages and describe how to apply the basic principles of holonic systems in intelligent information systems with a focus on real-time applications. We also survey the basic concepts and reference taxonomy, providing an overview of the expected transition from traditional manufacturing and automation systems to holonic intelligent systems.