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In safety-critical (software) systems, safety management embraces both processes and products, which due to e.g., product's upgrade, tend to be tailored, giving rise to safety-oriented product lines and corresponding safety-oriented process lines. To tailor these lines systematically, their inter-dependencies would have been taken into consideration. To date, however, no satisfying implemented solution is available on the shelf. Accordingly, this paper focuses on the co-engineering of process and product lines. At first, the process and product lines need to be established for which the integration between Eclipse Process Framework (EPF) Composer, Composition with Guarantees for High-integrity Embedded Software Components Assembly (CHESS) Tool and Base Variability Resolution (BVR) Tool is achieved; they are process engineering, product design and variant management solutions, respectively. After that, the process and product lines are integrated. This is done for cross-dimension variant management and change impact analysis. The applicability of the integrated lines is illustrated for the attitude and orbit control subsystem.