While systems of systems (SoS) are starting to reach the market, it is not entirely evident how to analyze safety, and on a high level also security, of such systems. In fact, speci c characteristics of SoS, such as independence, changing con- stitution, evolutionary development, and emergent behavior, provide certain challenges to the safety analysis. In this pa- per, such challenges are summarized and a systems theoretic safety analysis method, abbreviated as STAMP, is evaluated on an automotive SoS application example. In conclusion, STAMP seems well positioned to serve as a base for a future method for safety and, to a certain degree, security analysis of SoS, although some work remains to be done. The advan- tages and limitations of the STAMP approach when dealing with SoS are discussed.