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The UGT2B17 gene deletion is not associated with prostate cancer risk
Karolinska Univ Hosp, Dept Urol, SE-14186 Stockholm, Sweden..
Umea Univ, Dept Radiat Sci, Umea, Sweden..
Umea Univ Hosp, Ctr Oncol, S-90185 Umea, Sweden..
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA..
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2008 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 68, no 5, p. 571-575Article in journal (Refereed) Published
Abstract [en]

BACKGROUND. Deletion polymorphism of the UDP-glucuronosyltransferase 2B17 (UG'T2B17) gene has been associated with an increased prostate cancer risk in two previous independent studies. Here we determine the risk in a large-scale population-based case-control study. METHODS. Genotyping was conducted with a 5'-nuclease activity assay to distinguish those with one or two UGT2B17 gene copies (ins/del and ins/ins) from individuals homozygous for the deletion (del/del) allele. RESULTS. In contrast to previous findings, no association between the UGT2B17 deletion polymorphism and prostate cancer risk was found. Furthermore the UGT2B17 gene deletion did not affect the risk for prostate cancer specific death. CONCLUSION. The UGT2B17 deletion polymorphism does not play a major role in prostate cancer susceptibility as previously indicated.

Place, publisher, year, edition, pages
WILEY-LISS , 2008. Vol. 68, no 5, p. 571-575
Keywords [en]
prostate cancer, UGT2B17, androgens, case-control study
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:mdh:diva-40706DOI: 10.1002/pros.20700ISI: 000254726500011PubMedID: 18247404OAI: oai:DiVA.org:mdh-40706DiVA, id: diva2:1246086
Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2018-09-06Bibliographically approved

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Bälter, Katarina

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