Changes in their daily lives that patients endure because of hemodialysis are major and also essential so they can stay alive. The aim of this study was to describe changes in life for patients with renal failure undergoing hemodialysis. The study has a qualitative descriptive approach with a qualitative content analysis based on in-depth interviews with patients undergoing hemodialysis. Results show that life in hemodialysis is experienced as a transition from liberty to captivity, adjusting to the new life, and the new life moving towards reconciliation. This study shows that support towards reconciliation is crucial for patient health.