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Improvement of biocompatibility of neuroprosthesis devices for long term use; an initial assessment
Mälardalen University, School of Sustainable Development of Society and Technology.
2008 (English)Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Abstract

The aim of this project was to contribute to the improvement of Neuroprobe arrays regarding the biocompatibility by providing those with three different modified biopolymers, either hyaluronic acid, dextran or poly(ethylene glycol). In addition, the biopolymers were tested with two different molecular weights. To get a deeper understanding of the behaviour and configuration of the biopolymers on surfaces, gold, native silicon oxide and artificially made silicon oxide wafers were immobilised with the modified biopolymers and analysed with Atomic Force Microscope and X-ray Photoelectron Spectroscopy. Furthermore, derivatisations of the biopolymers were carried out and in some extent they were amended if possible. The task was to find out which one of the three biopolymers being most suited in the context.

The first step was to provide the biopolymers with a SS-pyridyl group. The SS-Pyridyl group is reactive towards the gold wafer surface and towards the thiols introduced on the native silicon oxide and the artificial made silicon oxide wafer surfaces via a mercaptopropyl derivatisation. The second step was to immobilise the biopolymers on the gold, native silicon oxide and artificial silicon oxide wafer surfaces and then to analyse them with Atomic Force Microscope and X-ray Photoelectron Spectroscopy. The former step was performed at Mälardalens University and the latter step was performed at Ångströms Laboratory, Uppsala University.

Atomic Force Microscope pictures and X-ray Photoelectron Spectroscopy measurements were analyzed and evaluated in order to find the biopolymer most suited in the context. In addition, poly(ethylene glycol) was cut from the project leaving the two remaining biopolymers, hyaluronic acid and dextran, open for persual. The outcome gave the hyaluronic acid a slight advantage over dextran considering the results of this project and also the fact that hyaluronic acid occurs as a natural substance within the brain of mammals. Moreover, the surface which the biopolymers were immobilised on did matter. The conformation of the biopolymer seemed to change depending on the surfaces composition. In contrast, the molecular weight of the biopolymers seemed to have less influence.

Place, publisher, year, edition, pages
Akademin för hållbar samhälls- och teknikutveckling , 2008. , p. 48
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:mdh:diva-588OAI: oai:DiVA.org:mdh-588DiVA, id: diva2:121170
Presentation
2008-02-01, Filen, Verktyget, 13:00 (English)
Uppsok
Technology
Supervisors
Examiners
Available from: 2009-12-16 Created: 2008-04-08 Last updated: 2009-12-16Bibliographically approved

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