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Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study
Uppsala University Hospital, Uppsala, Sweden .
Uppsala University Hospital, Uppsala, Sweden .
Uppsala University Hospital, Uppsala, Sweden .
University of Texas Medical Branch, Galveston, TX, United States.
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2005 (English)In: APMIS., Vol. 113, no 2, p. 126-134Article in journal (Refereed) Published
Abstract [en]

Sweden is an area potentially endemic for spotted fever rickettsioses. Rickettsia helvetica has been isolated from its tick vector Ixodes ricinus, and in a handful of cases linked to human disease. This study demonstrates for the first time in Sweden the transmission of rickettsial infection after a tick bite and the attack rate in an endemic area. We present three cases of documented rickettsial infection and a prospective serological study of Swedish recruits who were trained in the area where the patients lived and showed seroconversion to spotted fever rickettsiae. All patients showed a four-fold increase in antibody titer to the spotted fever rickettsia, R. helvetical and immunohistochemical examination revealed rickettsia-like organisms in the walls of skin capillaries and veins. Electron microscopy showed organisms resembling R. helvetica and immunogold labeling with two anti-rickettsial antibodies demonstrated specific labeling of the rickettsial organisms in the skin biopsy specimens. Eight of the thirty-five recruits showed a four-fold increase in IgG titer reflecting a high rate of exposure. The results of this study demonstrate that spotted fever rickettsioses should be taken into consideration in the diagnosis of tick-transmitted infections in Sweden.

Place, publisher, year, edition, pages
2005. Vol. 113, no 2, p. 126-134
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:mdh:diva-3098DOI: 10.1111/j.1600-0463.2005.apm1130206.xISI: 000227626700006Scopus ID: 2-s2.0-14844283403OAI: oai:DiVA.org:mdh-3098DiVA, id: diva2:115762
Available from: 2008-03-31 Created: 2008-03-31 Last updated: 2015-06-02Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf