Folate and vitamin B-12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
2017 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 117, no 1, 124-133 p.Article in journal (Refereed) Published
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, E-50009 Zaragoza, Spain.;Inst Salud Carlos III, Red Salud Maternoinfantil Desarrollo SAMID, C Monforte de Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain..
Univ Ghent, Univ Hosp, Dept Publ Hlth, De Pintelaan 185,Entrance 42,Bldg K3,4th Floor, B-9000 Ghent, Belgium.;IARC, 150 Cours Albert Thomas, F-69372 Lyon 08, France..
Univ Politecn Madrid, Dept Hlth & Human Performance, ImFINE Res Grp, C Martin Fierro 7, E-28040 Madrid, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, C Monforte de Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain..
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, E-50009 Zaragoza, Spain..
This study aimed to examine the association between vitamin B-6, folate and vitamin B-12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43% males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found with n-6: n-3 ratio, trans-fatty acids and oleic: stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15.85 mu mol/l of EPA (P value < 0.01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2.06 mu mol/l of DHA (P value < 0.05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.
Place, publisher, year, edition, pages
CAMBRIDGE UNIV PRESS , 2017. Vol. 117, no 1, 124-133 p.
Fatty acids, B-vitamins, Adolescents, Europe
IdentifiersURN: urn:nbn:se:mdh:diva-35125DOI: 10.1017/S0007114516004414ISI: 000395508700011PubMedID: 28098048OAI: oai:DiVA.org:mdh-35125DiVA: diva2:1087263