The purpose of this paper is to investigate how the development of a strategically integrated product and production system portfolio could be enabled by the concept of reconfigurable manufacturing. In previous research, several critical challenges related to developing production system portfolios have been identified, but it has not been investigated how developing a reconfigurable manufacturing concept could aid some of these. Therefore, through a multiple case study, these critical challenges have been investigated in two companies that have recently developed reconfigurable manufacturing concepts for multiple variants and generations of products. The findings reveal that the companies need to deal with several challenges in order to enable a functioning RMS. By running the project separately from the NPD project and to include several product types and production sites the company overcome several challenges. (C) 2016 The Authors. Published by Elsevier B.V.