mdh.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Microtubule associated proteins 1B and 1S: interactions with NR1 and NR3A
Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling.
2008 (engelsk)Independent thesis Advanced level (degree of Master), 20 poäng / 30 hpOppgave
Abstract [en]

 

In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the N-methyl-D-aspartate receptor subunit NR3A (Eriksson et. al.)1.  In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the microtubule-associated protein 1S carboxyl-terminus and the N-methyl-D-aspartate receptor subunits NR1 and NR3A were examined. The study showed that an interaction occurred between amino acids 2167 to 2365 of the microtubule-associated protein 1B and NR3A.  That region of microtubule associated protein 1B corresponds to a microtubule-binding region in the light chain. It has been shown in earlier studies (Reviewed in Halpain S. et a12, Riederer, BM.  et.al3.) that the light chain is a active part of the protein that have been post translational cleaved. The MAP 1 proteins are present in all tissue but has higher concentrations in the Post Synaptic Density of neurons in the central nervous system.  The N-methyl-D-aspartate receptors are present in glial cells and in the dendritic shafts of the central nervous system neurons (Eriksson et. al.)1 . The diseases were these proteins may play a part is mainly memory destructive diseases such as Alzheimers disease and in muscular dystrophy, but these assumptions are still being speculated.

 

sted, utgiver, år, opplag, sider
2008. , s. 19
Emneord
NR1, NR3A, NMDA, Microtubule associated proteins, MAP1S, MAP1B
HSV kategori
Identifikatorer
URN: urn:nbn:se:mdh:diva-1197OAI: oai:DiVA.org:mdh-1196DiVA, id: diva2:37558
Presentation
(engelsk)
Uppsök
fysik/kemi/matematik
Veileder
Examiner
Tilgjengelig fra: 2008-10-13 Laget: 2008-10-07 Sist oppdatert: 2008-10-13bibliografisk kontrollert

Open Access i DiVA

fulltekst(0 kB)228 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 0 kBChecksum SHA-512
ee5ad5639752cfe3d6867d6b3d6c48035f722c548bbccea247e47762421340c4dd9037d65a40d0753af89ae98cffc9a1131cb8092adbe3e626d605b7b080cf73
Type fulltextMimetype application/pdf

Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 228 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

urn-nbn

Altmetric

urn-nbn
Totalt: 262 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf