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Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults
Univ So Denmark, Alcohol Res Ctr, Natl Inst Publ Hlth, DK-1399 Copenhagen K, Denmark.;Univ Copenhagen, Dept Publ Hlth, Social Med Sect, Copenhagen, Denmark..
Univ So Denmark, Alcohol Res Ctr, Natl Inst Publ Hlth, DK-1399 Copenhagen K, Denmark..ORCID iD: 0000-0002-9796-3967
Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark..
Copenhagen Univ Hosp, Ctr Hlth & Soc, Inst Prevent Med, Res Unit Dietary Studies, Copenhagen, Denmark..
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2010 (English)In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 121, no 14, p. 1589-1597Article in journal (Refereed) Published
Abstract [en]

Background-Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men <40 years of age and in women <50 years of age; for this reason, study cohorts rarely have the power to investigate the effects of alcohol on coronary heart disease risk in younger adults. This study examined whether the beneficial effect of alcohol on coronary heart disease depends on age. Methods and Results-In this pooled analysis of 8 prospective studies from North America and Europe including 192 067 women and 74 919 men free of cardiovascular diseases, diabetes, and cancers at baseline, average daily alcohol intake was assessed at baseline with a food frequency or diet history questionnaire. An inverse association between alcohol and risk of coronary heart disease was observed in all age groups; hazard ratios among moderately drinking men (5.0 to 29.9 g/d) 39 to 50, 50 to 59, and >= 60 years of age were 0.58 (95% confidence interval [CI], 0.36 to 0.93), 0.72 (95% CI, 0.60 to 0.86), and 0.85 (95% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90% CI, 44 to 140) adults. Similar results were observed in women. Conclusion-Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults. (Circulation. 2010; 121: 1589-1597.)

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2010. Vol. 121, no 14, p. 1589-1597
Keywords [en]
age groups, alcohol consumption, coronary disease, epidemiology
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:mdh:diva-40697DOI: 10.1161/CIRCULATIONAHA.109.887513ISI: 000276530600004PubMedID: 20351238OAI: oai:DiVA.org:mdh-40697DiVA, id: diva2:1246096
Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2018-09-06Bibliographically approved

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Bälter, Katarina

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