This study proposes a model, process and guidelines supporting the creation of global high-performing innovation teams. As global innovation work by teams has become more common, global companies conducting or aiming to conduct global innovation work would benefit from using the suggested proposals. Through a two-pronged research approach, data were collected through a systematic literature review to identify key factors enabling global innovation work from the innovation team perspective and its context, which were validated through interviews and questionnaires with senior management, management, and team members involved in innovation teams spanning six countries. The analysis enabled the proposition of an original model describing a global high-performing innovation team and its context and perspectives alongside a process and guidelines to create such teams in practice, adding knowledge to previous literature, particularly the research field of Innovation Management. Limitations and further research are discussed.