https://www.mdu.se/

mdu.sePublications
Planned maintenance
A system upgrade is planned for 10/12-2024, at 12:00-13:00. During this time DiVA will be unavailable.
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Action of CB1 and CB2 antagonists/inverse agonists on mantle cell lymphoma
Mälardalen University, School of Sustainable Development of Society and Technology.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

In this study, the effects of antagonists to the cannabinoid receptors in MCL cell lines were studied. Results presented in this study show that signalling through cannabinoid receptor with antagonists such as SR141716, SR144528 decreases cell viability but hemopressin when analyzing with XTT. The decrease in cell viability by SR141716 is caused by apoptosis triggered after 5 hours of treatment. The CB1 expression was confirmed in all MCL cell lines tested via western blotting but the expression of CB2 and GPR55 – another receptor to which SR141716 has affinity - was not confirmed due to lack of reliable antibodies. Specific agonist to GPR55 – LPI (l-α-lysophosphatidylinositol) showed different response compared to SR141716 which suggests that the effect seen by SR141716 was not induced through GPR55. The effect induced by CB1/CB2 agonist AEA is shown to be neither through CB1 or CB2 alone but possibly on another receptor yet to be described.

Place, publisher, year, edition, pages
2011.
Identifiers
URN: urn:nbn:se:mdh:diva-12236OAI: oai:DiVA.org:mdh-12236DiVA, id: diva2:416062
Uppsok
Life Earth Science
Examiners
Available from: 2011-10-12 Created: 2011-05-10 Last updated: 2011-10-12Bibliographically approved

Open Access in DiVA

Action of CB1 and CB2 antagonists/inverse agonists on mantle cell lymphoma(711 kB)494 downloads
File information
File name FULLTEXT01.pdfFile size 711 kBChecksum SHA-512
ada81731dd72ab9f3c7f4ae06a14df8ed768a8e2517ba28e1ff3b3cf8ab6beec80ef8a10cf1e9a1f6ade0361dd858763c53f4901b8435f0fb17b463a1758f286
Type fulltextMimetype application/pdf

By organisation
School of Sustainable Development of Society and Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 494 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 358 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf