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Bonn, S. E., Holmberg, E., Hugosson, J. & Bälter, K. (2020). Is leisure time sitting associated with mortality rates among men diagnosed with localized prostate cancer?. European Journal of Cancer Prevention, 29(2), 134-140
Öppna denna publikation i ny flik eller fönster >>Is leisure time sitting associated with mortality rates among men diagnosed with localized prostate cancer?
2020 (Engelska)Ingår i: European Journal of Cancer Prevention, ISSN 0959-8278, E-ISSN 1473-5709, Vol. 29, nr 2, s. 134-140Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Being physically active postdiagnosis has been associated with lower rates of prostate cancer progression and mortality, but studies investigating postdiagnostic time spent sitting are lacking. We aim to study the association between leisure time sitting after a prostate cancer diagnosis and overall and prostate cancer-specific mortality. METHODS: Data from 4595 men in Sweden, diagnosed with localized prostate cancer between 1997-2002 and followed-up until the end of 2012, were analyzed. Time spent sitting during leisure time postdiagnosis was categorized into <2, 2-3, 3-4, and >4 h/day. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) of postdiagnosis leisure time sitting and a joint variable of sitting time and exercise, and time to overall or prostate cancer-specific death. RESULTS: The results showed no significant associations between postdiagnostic leisure time sitting and overall or prostate cancer-specific mortality rates. When the joint effect of both sitting and exercise time was considered, borderline significantly lower mortality rates for overall and prostate cancer-specific mortality were seen among participants that sat the least and exercised the most compared to the reference category with participants sitting the most and exercising least (HR: 0.75; 95% CI: 0.56-1.00 and HR: 0.61; 95% CI: 0.36-1.05, respectively). CONCLUSIONS: No significant association between leisure time sitting and mortality rates among men diagnosed with localized prostate cancer was seen. This study does not support an association between leisure time sitting per se; however, being physically active may have beneficial effects on survival among men diagnosed with localized prostate cancer.

Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-47024 (URN)10.1097/CEJ.0000000000000523 (DOI)2-s2.0-85078869634 (Scopus ID)
Tillgänglig från: 2020-02-13 Skapad: 2020-02-13 Senast uppdaterad: 2020-02-13Bibliografiskt granskad
Bälter, K. (2019). Climate friendly food habits and risk factors for cardiovascular disease in young adults in the LifeGene study. In: : . Paper presented at The 3rd Agriculture and Climate Change Conference will take place at the Novotel Budapest City, Budapest, Hungary.
Öppna denna publikation i ny flik eller fönster >>Climate friendly food habits and risk factors for cardiovascular disease in young adults in the LifeGene study
2019 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Övrigt vetenskapligt)
Abstract [en]

Background: Different food products, and thus also diets, are associated with various levels of greenhouse gas emission. Animal food products typically cause larger emissions than plant-based products and it would be beneficial for the climate to limit the global consumption of beef and dairy products while increasing the intake of vegetables, legumes, and grains.

Aim: We will relate a climate friendly diet to individual risk factors for cardiovascular disease (CVD) such as overweight, triglyceride levels, HDL cholesterol levels, systolic and diastolic blood pressure and glucose levels, as well as a combination of risk factors, i.e. a proxy of the metabolic syndrome.

Method: LCA data expressed as kilogram COequivalents per kilogram of food products (kg CO2e/kg) were linked to the dietary intake in the LifeGene study of 5,364 subjects in Sweden.

Results: A diet generating high levels of CO2e was associated with higher BMI, waist circumference and body fat than a diet with lower levels of CO2e.

Conclusions: A climate friendly diet is also a healthy diet i.e. a win-win situation.

Nyckelord
greenhouse gas emission diet
Nationell ämneskategori
Naturvetenskap Hälsovetenskaper
Forskningsämne
folkhälsovetenskap
Identifikatorer
urn:nbn:se:mdh:diva-46066 (URN)
Konferens
The 3rd Agriculture and Climate Change Conference will take place at the Novotel Budapest City, Budapest, Hungary
Tillgänglig från: 2019-11-15 Skapad: 2019-11-15 Senast uppdaterad: 2019-12-17Bibliografiskt granskad
Li, L., Taylor, M., Bälter, K., Chen, Q., Hegvik, T.-A., Thompson, A., . . . Larsson, H. (2019). Genetic and environmental contributions to the association between ADHD symptoms and unhealthy dietary habits in adulthood: a large population-based twin study. Paper presented at 49th Annual Meeting of the Behavior-Genetics-Association (BGA), JUN 26-29, 2019, Karolinska Inst, Stockholm, SWEDEN. Behavior Genetics, 49(6), 511-512
Öppna denna publikation i ny flik eller fönster >>Genetic and environmental contributions to the association between ADHD symptoms and unhealthy dietary habits in adulthood: a large population-based twin study
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2019 (Engelska)Ingår i: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 49, nr 6, s. 511-512Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
SPRINGER, 2019
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-46312 (URN)000494050500092 ()
Konferens
49th Annual Meeting of the Behavior-Genetics-Association (BGA), JUN 26-29, 2019, Karolinska Inst, Stockholm, SWEDEN
Tillgänglig från: 2019-12-12 Skapad: 2019-12-12 Senast uppdaterad: 2019-12-12Bibliografiskt granskad
Wiklund, C. A., Kuja-Halkola, R., Thornton, L. M., Bälter, K., Welch, E. & Bulik, C. M. (2018). Childhood body mass index and development of eating disorder traits across adolescence. European eating disorders review, 26(5), 462-471
Öppna denna publikation i ny flik eller fönster >>Childhood body mass index and development of eating disorder traits across adolescence
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2018 (Engelska)Ingår i: European eating disorders review, ISSN 1072-4133, E-ISSN 1099-0968, Vol. 26, nr 5, s. 462-471Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Understanding the role of premorbid body mass index (BMI) in the emergence of eating disorders may be key to identifying effective prevention strategies. We explore relations between BMI and eating disorders traits in young twins. Method: The effect of BMI at age 9/12 and 15 on eating disorder traits measured using the Eating Disorders Inventory-2 (EDI) at ages 15 and 18 was examined using bivariate modelling in a longitudinal population sample of Swedish twins. Results: The correlation between BMI and EDI within individuals was stable across all ages and remained significant after adjusting for later BMI. Bivariate analysis indicated significant positive genetic correlations between BMI ages 9/12 and 15 and subsequent EDI scores. The relationship remained significant for BMI age 9/12 and EDI age 15 in the adjusted model, indicating a longitudinal association. Conclusion: Our results have implications for conceptualizing the interrelation of BMI and eating disorders across childhood and adolescence. 

Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40363 (URN)10.1002/erv.2612 (DOI)000440549500008 ()29927002 (PubMedID)2-s2.0-85050972141 (Scopus ID)
Tillgänglig från: 2018-08-17 Skapad: 2018-08-17 Senast uppdaterad: 2019-11-15
Sjors, C., Hedenus, F., Sjolander, A., Tillander, A. & Bälter, K. (2017). Adherence to dietary recommendations for Swedish adults across categories of greenhouse gas emissions from food. Public Health Nutrition, 20(18), 3381-3393
Öppna denna publikation i ny flik eller fönster >>Adherence to dietary recommendations for Swedish adults across categories of greenhouse gas emissions from food
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2017 (Engelska)Ingår i: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 20, nr 18, s. 3381-3393Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To explore associations between diet-related greenhouse gas emissions (GHGE), nutrient intakes and adherence to the Nordic Nutrition Recommendations among Swedish adults. Design: Diet was assessed by 4 d food records in the Swedish National Dietary Survey. GHGE was estimated by linking all foods to carbon dioxide equivalents, using data from life cycle assessment studies. Participants were categorized into quartiles of energy-adjusted GHGE and differences between GHGE groups regarding nutrient intakes and adherence to nutrient recommendations were explored. Setting: Sweden. Subjects: Women (n 840) and men (n 627) aged 18-80 years. Results: Differences in nutrient intakes and adherence to nutrient recommendations between GHGE groups were generally small. The dietary intake of participants with the lowest emissions was more in line with recommendations regarding protein, carbohydrates, dietary fibre and vitamin D, but further from recommendations regarding added sugar, compared with the highest GHGE group. The overall adherence to recommendations was found to be better among participants with lower emissions compared with higher emissions. Among women, 27% in the lowest GHGE group adhered to at least twenty-three recommendations compared with only 12% in the highest emission group. For men, the corresponding figures were 17 and 10 %, respectively. Conclusions: The study compared nutrient intakes as well as adherence to dietary recommendations for diets with different levels of GHGE from a national dietary survey. We found that participants with low-emission diets, despite higher intake of added sugar, adhered to a larger number of dietary recommendations than those with high emissions.

Ort, förlag, år, upplaga, sidor
CAMBRIDGE UNIV PRESS, 2017
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-38585 (URN)10.1017/S1368980017002300 (DOI)000423197700020 ()28879831 (PubMedID)2-s2.0-85030833631 (Scopus ID)
Tillgänglig från: 2018-02-08 Skapad: 2018-02-08 Senast uppdaterad: 2019-11-15
Raposo, S. E., Fondell, E., Strom, P., Balter, O., Bonn, S. E., Nyren, O., . . . Bälter, K. (2017). Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study. European Journal of Clinical Nutrition, 71(4), 450-457
Öppna denna publikation i ny flik eller fönster >>Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study
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2017 (Engelska)Ingår i: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 71, nr 4, s. 450-457Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND/OBJECTIVES: Antioxidants and polyunsaturated fatty acids (PUFAs) have a role in the human immune defense and may affect the susceptibility to upper respiratory tract infection (URTI). To examine dietary intake of vitamin C, vitamin E, selenium, zinc and PUFAs in relation to URTI incidence in a prospective cohort study. SUBJECTS/METHODS: A total of 1533 Swedish women and men aged 25-64 years were followed for nine months during 2011-2012. Information on dietary intake was assessed through a web-based food frequency questionnaire, and events of URTI were self-reported prospectively as they occurred. Cox proportional hazards regression was applied to obtain incidence rate ratios with 95% confidence intervals. RESULTS: The mean number of URTI events was 0.9 among all participants, 1.0 among women and 0.7 among men. In women, the incidence rate ratios ( 95% confidence interval) for high compared with low intake were 0.69 (0.55-0.88) for vitamin C, 0.77 (0.62-0.96) for vitamin E, 0.57 (0.39-0.83) for docosahexaenoic acid (DHA) and 0.80 (0.65-0.99) for arachidonic acid ( AA). No association was found for selenium or zinc among women. In men, an increased URTI incidence was seen with medium vitamin E intake (1.42 (1.09-1.85)) and high zinc intake (1.50 (1.04-2.16)). No association was found for vitamin C, selenium or PUFAs among men. CONCLUSIONS: We found an inverse association of URTI incidence among women for vitamin C, vitamin E, DHA and AA intake and a positive association among men for vitamin E and zinc intake. The observed gender differences warrant further investigation.

Ort, förlag, år, upplaga, sidor
NATURE PUBLISHING GROUP, 2017
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40664 (URN)10.1038/ejcn.2016.261 (DOI)000398902800004 ()28074891 (PubMedID)
Tillgänglig från: 2018-09-06 Skapad: 2018-09-06 Senast uppdaterad: 2018-09-06Bibliografiskt granskad
Nystrom, C. D., Henriksson, H., Alexandrou, C., Bergstrom, A., Bonn, S., Bälter, K. & Lof, M. (2017). Validation of an Online Food Frequency Questionnaire against Doubly LabelledWater and 24 h Dietary Recalls in Pre-School Children. Nutrients, 9(1), Article ID 66.
Öppna denna publikation i ny flik eller fönster >>Validation of an Online Food Frequency Questionnaire against Doubly LabelledWater and 24 h Dietary Recalls in Pre-School Children
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2017 (Engelska)Ingår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 9, nr 1, artikel-id 66Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The development of easy-to-use and accurate methods to assess the intake of energy, foods and nutrients in pre-school children is needed. KidMeal-Q is an online food frequency questionnaire developed for the LifeGene prospective cohort study in Sweden. The aims of this study were to compare: (i) energy intake (EI) obtained using KidMeal-Q to total energy expenditure (TEE) measured via doubly labelled water and (ii) the intake of certain foods measured using KidMeal-Q to intakes acquired by means of 24 h dietary recalls in 38 children aged 5.5 years. The mean EI calculated using KidMeal-Q was statistically different (p < 0.001) from TEE (4670 +/- 1430 kJ/24 h and 6070 +/- 690 kJ/24 h, respectively). Significant correlations were observed for vegetables, fruit juice and candy between KidMeal-Q and 24 h dietary recalls. Only sweetened beverage consumption was significantly different in mean intake (p < 0.001), as measured by KidMeal-Q and 24 h dietary recalls. In conclusion, KidMeal-Q had a relatively short answering time and comparative validity to other food frequency questionnaires. However, its accuracy needs to be improved before it can be used in studies in pre-school children.

Ort, förlag, år, upplaga, sidor
MDPI AG, 2017
Nyckelord
doubly labelled water, food frequency questionnaire, 24 h dietary recalls, pre-school
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40665 (URN)10.3390/nu9010066 (DOI)000396465500065 ()
Tillgänglig från: 2018-09-06 Skapad: 2018-09-06 Senast uppdaterad: 2018-09-06Bibliografiskt granskad
Bonn, S. E., Sjolander, A., Tillander, A., Wiklund, F., Gronberg, H. & Bälter, K. (2016). Body mass index in relation to serum prostate-specific antigen levels and prostate cancer risk. International Journal of Cancer, 139(1), 50-57
Öppna denna publikation i ny flik eller fönster >>Body mass index in relation to serum prostate-specific antigen levels and prostate cancer risk
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2016 (Engelska)Ingår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 139, nr 1, s. 50-57Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

High Body mass index (BMI) has been directly associated with risk of aggressive or fatal prostate cancer. One possible explanation may be an effect of BMI on serum levels of prostate-specific antigen (PSA). To study the association between BMI and serum PSA as well as prostate cancer risk, a large cohort of men without prostate cancer at baseline was followed prospectively for prostate cancer diagnoses until 2015. Serum PSA and BMI were assessed among 15,827 men at baseline in 2010-2012. During follow-up, 735 men were diagnosed with prostate cancer with 282 (38.4%) classified as high-grade cancers. Multivariable linear regression models and natural cubic linear regression splines were fitted for analyses of BMI and log-PSA. For risk analysis, Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) and natural cubic Cox regression splines producing standardized cancer-free probabilities were fitted. Results showed that baseline Serum PSA decreased by 1.6% (95% CI: -2.1 to -1.1) with every one unit increase in BMI. Statistically significant decreases of 3.7, 11.7 and 32.3% were seen for increasing BMI-categories of 25<30, 30<35 and 35 kg/m(2), respectively, compared to the reference (18.5<25 kg/m(2)). No statistically significant associations were seen between BMI and prostate cancer risk although results were indicative of a positive association to incidence rates of high-grade disease and an inverse association to incidence of low-grade disease. However, findings regarding risk are limited by the short follow-up time. In conclusion, BMI was inversely associated to PSA-levels. BMI should be taken into consideration when referring men to a prostate biopsy based on serum PSA-levels. What's new? High body mass index (BMI) has been associated with risk of aggressive or fatal prostate cancer. One possible explanation may be an effect on serum prostate-specific antigen (PSA) levels. Here, the authors assessed the association between BMI and serum PSA level and prostate cancer risk in a large prospective cohort study. While no statistically significant associations were found between BMI and overall risk of prostate cancer, increasing BMI was associated with decreased serum PSA levels among men with no previous prostate cancer diagnosis. BMI should be taken into consideration when referring men to a prostate biopsy based on PSA-test results.

Ort, förlag, år, upplaga, sidor
WILEY-BLACKWELL, 2016
Nyckelord
body mass index, incidence, prostate cancer, prostate specific antigen
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40667 (URN)10.1002/ijc.30052 (DOI)000374381400008 ()26914149 (PubMedID)
Tillgänglig från: 2018-09-06 Skapad: 2018-09-06 Senast uppdaterad: 2018-09-06Bibliografiskt granskad
Moller, E., Wilson, K. M., Batista, J. L., Mucci, L. A., Bälter, K. & Giovannucci, E. (2016). Body size across the life course and prostate cancer in the Health Professionals Follow-up Study. International Journal of Cancer, 138(4), 853-865
Öppna denna publikation i ny flik eller fönster >>Body size across the life course and prostate cancer in the Health Professionals Follow-up Study
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2016 (Engelska)Ingår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 138, nr 4, s. 853-865Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow-up Study. We assessed adult height, body mass index (BMI) in early and middle-to-late adulthood, adult waist circumference, and body shape at age 10. With follow-up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced-stage tumors, particularly fatal disease (RR=1.66, 95% CI 1.23-2.23, highest vs. lowest quintile, p(trend) < 0.001). High BMI at age 21 was inversely associated with total prostate cancer (RR=0.89, 95% CI 0.80-0.98, BMI >= 26 vs. 20-21.9, p(trend)=0.01) and with fatal and advanced disease. The association for late adult BMI differed by age (p(interaction) < 0.001); high BMI was inversely associated with total prostate cancer (RR=0.64, 95% CI 0.51-0.78, BMI >= 30 vs. 21-22.9, p(trend) < 0.001) and with non-advanced and less aggressive tumors among men <= 65 years, whereas no association was seen among men >65 years. Adult waist circumference was weakly inversely associated with less aggressive disease. Childhood obesity was unclearly related to risk. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. The influence of adiposity varies by prognostic disease subtype and by age. The relationship between body size and prostate cancer is complex. Body size changes progressively throughout life and consequent effects on prostate cancer risk may be associated with related changes in hormonal and metabolic pathways. This large prospective study examined potential associations between the risk of various prostate cancer subtypes and multiple anthropometric measures at different ages in men. Tallness was confirmed to be associated with an elevated risk of advanced prostate cancer, particularly fatal disease. The extent to which body weight influenced risk varied according to factors such as age and disease subtype.

Ort, förlag, år, upplaga, sidor
WILEY-BLACKWELL, 2016
Nyckelord
prostatic neoplasms, height, body mass index, childhood body size, waist circumference, epidemiology
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40668 (URN)10.1002/ijc.29842 (DOI)000369164200007 ()26355806 (PubMedID)
Tillgänglig från: 2018-09-06 Skapad: 2018-09-06 Senast uppdaterad: 2018-09-06Bibliografiskt granskad
Sjors, C., Raposo, S. E., Sjolander, A., Balter, O., Hedenus, F. & Bälter, K. (2016). Diet-related greenhouse gas emissions assessed by a food frequency questionnaire and validated using 7-day weighed food records. Environmental health, 15, Article ID 15.
Öppna denna publikation i ny flik eller fönster >>Diet-related greenhouse gas emissions assessed by a food frequency questionnaire and validated using 7-day weighed food records
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2016 (Engelska)Ingår i: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 15, artikel-id 15Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The current food system generates about 25 % of total greenhouse gas emissions (GHGE), including deforestation, and thereby substantially contributes to the warming of the earth's surface. To understand the association between food and nutrient intake and GHGE, we therefore need valid methods to assess diet-related GHGE in observational studies. Methods: Life cycle assessment (LCA) studies assess the environmental impact of different food items. We linked LCA data expressed as kg carbon dioxide equivalents (CO(2)e) per kg food product to data on food intake assessed by the food frequency questionnaire (FFQ) Meal-Q and validated it against a 7-day weighed food record (WFR). 166 male and female volunteers aged 20-63 years completed Meal-Q and the WFR, and their food intake was linked to LCA data. Results: The mean GHGE assessed with Meal-Q was 3.76 kg CO(2)e per day and person, whereas it was 5.04 kg CO(2)e using the WFR. The energy-adjusted and deattenuated Pearson and Spearman correlation coefficients were 0.68 and 0.70, respectively. Moreover, compared to the WFR, Meal-Q provided a good ranking ability, with 90 % of the participants classified into the same or adjacent quartile according to their daily average CO(2)e. The Bland-Altman plot showed an acceptable level of agreement between the two methods and the reproducibility of Meal-Q was high. Conclusions: This is the first study validating the assessment of diet-related GHGE by a questionnaire. The results suggest that Meal-Q is a useful tool for studying the link between food habits and CO(2)e in future epidemiological studies.

Ort, förlag, år, upplaga, sidor
BIOMED CENTRAL LTD, 2016
Nyckelord
Validation studies, Reproducibility of results, Food frequency questionnaire, Weighed food record, Epidemiology, Greenhouse gas emission, Climate change, Life cycle assessment, Carbon dioxide equivalents, Sustainable diets
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
urn:nbn:se:mdh:diva-40669 (URN)10.1186/s12940-016-0110-7 (DOI)000369630000001 ()26860262 (PubMedID)
Tillgänglig från: 2018-09-06 Skapad: 2018-09-06 Senast uppdaterad: 2018-09-06Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-2046-5641

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